PMID- 10797498
OWN - NLM
STAT- MEDLINE
DCOM- 20000519
LR  - 20190915
IS  - 0270-4137 (Print)
IS  - 0270-4137 (Linking)
VI  - 43
IP  - 3
DP  - 2000 May 15
TI  - Fluorescence in situ hybridization evaluation of c-myc and androgen receptor gene 
      amplification and chromosomal anomalies in prostate cancer in Japanese patients.
PG  - 225-32
AB  - BACKGROUND: Oncogene amplification and chromosomal anomalies are found in many 
      solid tumors and are often associated with aggressiveness of cancer. We evaluated 
      the frequency and the association of c-myc and androgen receptor (AR) gene 
      amplification and gain of chromosome 8 or X in prostate cancer in Japanese 
      patients. METHODS: We examined a total of 42 prostate cancer specimens, using 
      fluorescence in situ hybridization (FISH). Dual-labeling hybridization with a 
      directly labeled centromere probe for chromosome 8 or X together with a probe for 
      the c-myc or AR locus was performed. RESULTS: Gain of chromosome 8 was identified 
      in 54.8% of specimens and was associated with Gleason sum and nuclear anaplasia 
      in untreated prostate cancers. c-myc gene amplification was found in 14.3% of 
      specimens. Gain of chromosome X was identified in 42.9% of specimens. AR gene 
      amplification was detected in 0 of 37 untreated prostate cancers, but in 1 of 5 
      hormone-refractory prostate cancers. CONCLUSIONS: Our results suggest that c-myc 
      and AR gene amplification and gain of chromosome 8 or X may be associated with 
      the development and progression of prostate cancers. These results obtained in 
      Japanese cases are consistent with the results observed in prostate cancer in 
      Western countries.
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Miyoshi, Y
AU  - Miyoshi Y
AD  - Department of Urology, Yokohama City University School of Medicine, Kanazawa-ku, 
      Yokohama, Japan.
FAU - Uemura, H
AU  - Uemura H
FAU - Fujinami, K
AU  - Fujinami K
FAU - Mikata, K
AU  - Mikata K
FAU - Harada, M
AU  - Harada M
FAU - Kitamura, H
AU  - Kitamura H
FAU - Koizumi, Y
AU  - Koizumi Y
FAU - Kubota, Y
AU  - Kubota Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Prostate
JT  - The Prostate
JID - 8101368
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (Receptors, Androgen)
SB  - IM
MH  - Chromosome Aberrations
MH  - Chromosome Disorders
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 8
MH  - *Gene Amplification
MH  - Gene Frequency
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Japan
MH  - Male
MH  - Neoplasm Invasiveness
MH  - Prostatic Neoplasms/*genetics/pathology
MH  - Proto-Oncogene Proteins c-myc/*genetics
MH  - Receptors, Androgen/*genetics
MH  - *X Chromosome
EDAT- 2000/05/08 09:00
MHDA- 2000/06/08 09:00
CRDT- 2000/05/08 09:00
PHST- 2000/05/08 09:00 [pubmed]
PHST- 2000/06/08 09:00 [medline]
PHST- 2000/05/08 09:00 [entrez]
AID - 10.1002/(SICI)1097-0045(20000515)43:3<225::AID-PROS9>3.0.CO;2-7 [pii]
AID - 10.1002/(sici)1097-0045(20000515)43:3<225::aid-pros9>3.0.co;2-7 [doi]
PST - ppublish
SO  - Prostate. 2000 May 15;43(3):225-32. doi: 
      10.1002/(sici)1097-0045(20000515)43:3<225::aid-pros9>3.0.co;2-7.