PMID- 10798104
OWN - NLM
STAT- MEDLINE
DCOM- 20000601
LR  - 20190722
IS  - 0019-5456 (Print)
IS  - 0019-5456 (Linking)
VI  - 66
IP  - 4
DP  - 1999 Jul-Aug
TI  - Serum TNF-alpha and free radical scavengers in neonatal septicemia.
PG  - 511-6
AB  - Tumor necrosis factor-alpha (TNF-alpha) and free radicals have been implicated in 
      the pathogenesis of neonatal septicemia and its complications. This case control 
      study was conducted between November 1996 to July 1997 to determine the levels of 
      TNF-alpha and free radical scavengers viz. superoxide dismutase (SOD) and 
      glutathione peroxidase (GPX) in the serum of 30 septic neonates and 20 healthy 
      controls. Patients with neonatal sepsis registered significantly higher levels of 
      TNF-alpha, SOD and GPX in comparison to controls (p < 0.05). The neonates with 
      septic shock had five fold increase in TNF-alpha levels (2262 +/- 605.8 pg/ml) as 
      compared to those without shock (738.8 +/- 728.8 pg/ml). There was no 
      statistically significant difference in levels of antioxidant enzymes between 
      neonates with shock and without shock. The levels of TNF-alpha and antioxidant 
      enzymes were not affected by the type of organism isolated in blood culture.
FAU - Seema
AU  - Seema
AD  - Department of Pediatrics, Kalawati Saran Children's Hospital, New Delhi.
FAU - Kumar, R
AU  - Kumar R
FAU - Mandal, R N
AU  - Mandal RN
FAU - Tandon, A
AU  - Tandon A
FAU - Randhawa, V S
AU  - Randhawa VS
FAU - Mehta, G
AU  - Mehta G
FAU - Batra, S
AU  - Batra S
FAU - Ray, G N
AU  - Ray GN
FAU - Kapoor, A K
AU  - Kapoor AK
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Pediatr
JT  - Indian journal of pediatrics
JID - 0417442
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Case-Control Studies
MH  - Female
MH  - Free Radical Scavengers/blood
MH  - Glutathione Peroxidase/*blood
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Sepsis/*blood
MH  - Superoxide Dismutase/*blood
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 2000/05/08 09:00
MHDA- 2000/06/03 09:00
CRDT- 2000/05/08 09:00
PHST- 2000/05/08 09:00 [pubmed]
PHST- 2000/06/03 09:00 [medline]
PHST- 2000/05/08 09:00 [entrez]
AID - 10.1007/BF02727159 [doi]
PST - ppublish
SO  - Indian J Pediatr. 1999 Jul-Aug;66(4):511-6. doi: 10.1007/BF02727159.