PMID- 10799228
OWN - NLM
STAT- MEDLINE
DCOM- 20000627
LR  - 20161124
IS  - 0022-5347 (Print)
IS  - 0022-5347 (Linking)
VI  - 163
IP  - 6
DP  - 2000 Jun
TI  - Low incidence of new renal scars after ureteral reimplantation for vesicoureteral 
      reflux in children: a prospective study.
PG  - 1915-8
AB  - PURPOSE: The major aim of treating vesicoureteral reflux in children is the 
      prevention of renal scars. Dimercapto-succinic acid (DMSA) is the modality of 
      choice for detecting renal scars. We documented the incidence of new renal 
      scarring and measured changes in differential renal function after ureteral 
      reimplantation using DMSA studies. MATERIALS AND METHODS: We evaluated 45 boys 
      and 98 girls with a median age of 2 years who had vesicoureteral reflux and 
      underwent ureteral reimplantation. DMSA scans were done preoperatively and at a 
      median of 3.4 years postoperatively. Maximal reflux grade was III in 84 children 
      (59%), IV in 27 (19%) and V in 6 (4%). RESULTS: Preoperatively DMSA studies 
      showed scarred or contracted kidneys in 106 of the 143 patients (74%). After 
      reimplantation mean change in differential function was 2.5%. New scars developed 
      in 3 children (2%). We noted greater than 6% decrease in relative differential 
      function without new scarring in 7 cases (5%). CONCLUSIONS: The incidence of new 
      renal scars in our study using DMSA was lower than that in previous series using 
      excretory urography and imaging. Surgical correction of vesicoureteral reflux may 
      offer better protection of kidneys in childhood than previously believed.
FAU - Webster, R I
AU  - Webster RI
AD  - Departments of Urology and Nephrology, Sydney Children's Hospital, Prince of 
      Wales Hospital, Randwick, New South Wales, Australia.
FAU - Smith, G
AU  - Smith G
FAU - Farnsworth, R H
AU  - Farnsworth RH
FAU - Rossleigh, M A
AU  - Rossleigh MA
FAU - Rosenberg, A R
AU  - Rosenberg AR
FAU - Kainer, G
AU  - Kainer G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
RN  - 0 (Chelating Agents)
RN  - DX1U2629QE (Succimer)
SB  - IM
MH  - Adolescent
MH  - Chelating Agents
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prospective Studies
MH  - Radionuclide Imaging
MH  - *Replantation
MH  - Succimer
MH  - Ureter/*surgery
MH  - Vesico-Ureteral Reflux/diagnostic imaging/*surgery
EDAT- 2000/05/08 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/05/08 09:00
PHST- 2000/05/08 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/05/08 09:00 [entrez]
AID - S0022-5347(05)67597-0 [pii]
PST - ppublish
SO  - J Urol. 2000 Jun;163(6):1915-8.