PMID- 10801928
OWN - NLM
STAT- MEDLINE
DCOM- 20000607
LR  - 20181130
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 130
IP  - 5
DP  - 2000 May
TI  - Glucose-based oligosaccharides exhibit different in vitro fermentation patterns 
      and affect in vivo apparent nutrient digestibility and microbial populations in 
      dogs.
PG  - 1267-73
AB  - To evaluate the potential of indigestible oligosaccharides (OS) to serve as 
      "dietary fiber-like" ingredients, it is necessary to determine their extent of 
      indigestibility. In vitro fermentation characteristics of two novel OS, 
      alpha-glucooligosaccharides (GOS) and a maltodextrin-like OS (MD), were compared 
      to those of fructooligosaccharides (FOS), gum arabic (GA), guar gum (GG) and guar 
      hydrolysate (GH). Total short-chain fatty acid (SCFA) production (micromol/g dry 
      matter) as a result of MD fermentation was higher initially compared with GA 
      (P<0.01), but GA was more extensively fermented at 24 h (P<0.01). Total SCFA 
      production for GOS was similar to that for FOS, GG, GH and GA. In the second 
      experiment, GOS and MD were added at 6% to an enteral formula control diet 
      (Control) and fed to ileal-cannulated dogs in a 3x3 replicated Latin-square 
      design. Ileal digestibility of glucose was lower (P<0.05) and carbohydrate (CHO) 
      numerically lower (P = 0.08) for both GOS and MD compared with the Control. Total 
      tract digestibility of CHO and glucose was lower only for MD (P<0.01) compared 
      with the Control. Total fecal weights were higher (P<0.01) for both GOS and MD 
      treatments. Fecal concentration of bifidobacteria was numerically increased by 
      GOS and MD supplementation (P = 0.13 and 0.23, respectively). Thus, GOS and MD 
      are indigestible yet fermentable OS, and may act as "dietary fiber-like" 
      ingredients.
FAU - Flickinger, E A
AU  - Flickinger EA
AD  - Division of Nutritional Sciences and Department of Animal Sciences, University of 
      Illinois, Urbana, IL 61801, USA.
FAU - Wolf, B W
AU  - Wolf BW
FAU - Garleb, K A
AU  - Garleb KA
FAU - Chow, J
AU  - Chow J
FAU - Leyer, G J
AU  - Leyer GJ
FAU - Johns, P W
AU  - Johns PW
FAU - Fahey, G C Jr
AU  - Fahey GC Jr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Fatty Acids, Volatile)
RN  - 0 (Oligosaccharides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Bacteroides/*drug effects
MH  - Chromatography, High Pressure Liquid
MH  - *Diet
MH  - *Digestion/drug effects
MH  - Dogs
MH  - Enteral Nutrition
MH  - Fatty Acids, Volatile/*biosynthesis
MH  - Feces/*microbiology
MH  - Female
MH  - Fermentation
MH  - Glucose/metabolism
MH  - Hydrogen-Ion Concentration
MH  - Intestinal Mucosa/metabolism
MH  - Intestines/*microbiology
MH  - Oligosaccharides/administration & dosage/*pharmacology
MH  - Substrate Specificity
EDAT- 2000/05/10 09:00
MHDA- 2000/06/10 09:00
CRDT- 2000/05/10 09:00
PHST- 2000/05/10 09:00 [pubmed]
PHST- 2000/06/10 09:00 [medline]
PHST- 2000/05/10 09:00 [entrez]
AID - 10.1093/jn/130.5.1267 [doi]
PST - ppublish
SO  - J Nutr. 2000 May;130(5):1267-73. doi: 10.1093/jn/130.5.1267.