PMID- 10802224
OWN - NLM
STAT- MEDLINE
DCOM- 20000802
LR  - 20220318
IS  - 0891-5849 (Print)
IS  - 0891-5849 (Linking)
VI  - 28
IP  - 6
DP  - 2000 Mar 15
TI  - Is the endogenous peroxyl-radical scavenging capacity of plasma protective in 
      systemic inflammatory disorders in humans?
PG  - 926-33
AB  - Systemic inflammatory response syndrome (SIRS) in humans is associated with 
      heightened intravascular oxidative stress. The clinical significance of plasma 
      endogenous antioxidative capability in SIRS remains undetermined. Time-sequence 
      changes of plasma total radical-trapping antioxidant parameter (TRAP) and its 
      components were measured in 135 patients with various clinical conditions leading 
      to SIRS. The results were correlated with clinical parameters. Plasma TRAP 
      significantly depressed upon diagnosis of SIRS (SIRS vs. healthy subjects (n = 
      50), 605.7 +/- 20.4 vs. 803.4 +/- 30.8 microM Trolox equivalent, p <.001). In 
      survivors (n = 86), TRAP declined further during the course of SIRS, followed by 
      a mild recovery at the end of follow-up. General linear mixed model analysis 
      revealed that uric acid, vitamin C, vitamin E and unidentified antioxidants 
      contributed to most of the changes in TRAP (each factor p <.001). In nonsurvivors 
      (n = 49), TRAP increased steadily until death, and the increase was predominantly 
      the result of the increased contribution of bilirubin (p <.01). Higher TRAP 
      levels were not correlated with diminished blood oxidants formation (r = -0.13, 
      p.05), lower intensity of lipid peroxidation (r = 0.261, p <.05) or lesser 
      disease severity of SIRS. The results do not support the hypothesis that the 
      endogenous peroxyl radical scavenging ability of plasma plays a protective role 
      in the course of SIRS.
FAU - Tsai, K
AU  - Tsai K
AD  - Oxidative Stress Clinical Research Group and Division of Critical Care, 
      Department of Medicine, Taipei Veterans General Hospital, and National Yang-Ming 
      University School of Medicine, Taipei, Taiwan. kctsai@vghtpe.gov.tw
FAU - Hsu, T
AU  - Hsu T
FAU - Kong, C
AU  - Kong C
FAU - Lin, K
AU  - Lin K
FAU - Lu, F
AU  - Lu F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (Antioxidants)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Peroxides)
RN  - 3170-83-0 (perhydroxyl radical)
SB  - IM
MH  - Aged
MH  - Antioxidants/analysis
MH  - Female
MH  - Free Radical Scavengers/*blood/pharmacology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Peroxides/*blood
MH  - Systemic Inflammatory Response Syndrome/*blood
MH  - Time Factors
EDAT- 2000/05/10 09:00
MHDA- 2000/08/06 11:00
CRDT- 2000/05/10 09:00
PHST- 2000/05/10 09:00 [pubmed]
PHST- 2000/08/06 11:00 [medline]
PHST- 2000/05/10 09:00 [entrez]
AID - S0891584900001805 [pii]
AID - 10.1016/s0891-5849(00)00180-5 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 2000 Mar 15;28(6):926-33. doi: 
      10.1016/s0891-5849(00)00180-5.