PMID- 10802800
OWN - NLM
STAT- MEDLINE
DCOM- 20000530
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 54
IP  - 9
DP  - 2000 May 9
TI  - Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early 
      MS. Optic Neuritis Study Group.
PG  - 1859-61
AB  - The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI 
      signal abnormalities and with the development of MS was assessed in 178 patients 
      enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 
      85 (48%) of the 178 patients. Its presence was associated with increased odds of 
      probable or definite MS at 5 years (odds ratio, 1.92; 95% confidence interval, 
      1.01 to 3.67; p = 0.04). The association was most apparent among patients with 
      signal abnormalities on baseline brain MRI.
FAU - Hauser, S L
AU  - Hauser SL
AD  - Department of Neurology, University of California, San Francisco, CA, USA.
FAU - Oksenberg, J R
AU  - Oksenberg JR
FAU - Lincoln, R
AU  - Lincoln R
FAU - Garovoy, J
AU  - Garovoy J
FAU - Beck, R W
AU  - Beck RW
FAU - Cole, S R
AU  - Cole SR
FAU - Moke, P S
AU  - Moke PS
FAU - Kip, K E
AU  - Kip KE
FAU - Gal, R L
AU  - Gal RL
FAU - Long, D T
AU  - Long DT
LA  - eng
GR  - EY05435/EY/NEI NIH HHS/United States
GR  - NS26799/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (HLA-DR2 Antigen)
RN  - VB0R961HZT (Prednisone)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Alleles
MH  - Brain/drug effects/*pathology
MH  - Drug Therapy, Combination
MH  - Female
MH  - HLA-DR2 Antigen/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Infusions, Intravenous
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Methylprednisolone/administration & dosage/adverse effects
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnosis/drug therapy/genetics
MH  - Optic Neuritis/*diagnosis/drug therapy/genetics
MH  - Prednisone/administration & dosage/adverse effects
EDAT- 2000/05/10 09:00
MHDA- 2000/06/03 09:00
CRDT- 2000/05/10 09:00
PHST- 2000/05/10 09:00 [pubmed]
PHST- 2000/06/03 09:00 [medline]
PHST- 2000/05/10 09:00 [entrez]
AID - 10.1212/wnl.54.9.1859 [doi]
PST - ppublish
SO  - Neurology. 2000 May 9;54(9):1859-61. doi: 10.1212/wnl.54.9.1859.