PMID- 10803050
OWN - NLM
STAT- MEDLINE
DCOM- 20000602
LR  - 20181130
IS  - 0035-7820 (Print)
IS  - 0035-7820 (Linking)
VI  - 52
IP  - 10-12
DP  - 2000
TI  - [The biologically equivalent dose (BED): how solid is the calculation of this 
      factor? A consideration of margins of error of biologically equivalent dose].
PG  - 355-60
AB  - To predict the effect on tumours in radiotherapy, especially relating to 
      irreversible effects, but also to realize the retrospective assessment the so 
      called L-Q-model is relied on at present. Internal specific organ parameters, 
      such as alpha, beta, gamma, Tp, Tk, and rho, as well as external parameters, so 
      as D, d, n, V, and Vref, were used for determination of the biologically 
      equivalent dose BED. While the external parameters are determinable with small 
      deviations, the internal parameters depend on biological varieties and 
      dispersions: in some cases the lowest value is assumed to be delta = +/- 25%. 
      This margin of error goes on to the biologically equivalent dose by means of the 
      principle of superposition of errors. In some selected cases (lung, kidney, skin, 
      rectum) these margins of error were calculated exemplarily. The input errors 
      especially of the internal parameters cause a mean error delta on the 
      biologically equivalent dose and a dispersion of the single fraction dose d 
      dependent on the organ taking into consideration, of approximately 8-30%. Hence 
      it follows only a very critical and cautious application of those L-Q-algorithms 
      in expert proceedings, and in radiotherapy more experienced based decisions are 
      recommended, instead of acting only upon simple two-dimensional mechanistic 
      ideas.
FAU - Jensen, J M
AU  - Jensen JM
AD  - Klinik fur Strahlentherapie (Radioonkologie), Christian-Albrechts-Universitat, 
      Kiel.
FAU - Zimmermann, J
AU  - Zimmermann J
LA  - ger
PT  - Comparative Study
PT  - Journal Article
TT  - Die biologisch aquivalente Dosis BED--wie solide ist die Berechnung dieses 
      Faktors? Eine Betrachtung der Fehlerbalken der biologisch aquivalenten Dosis.
PL  - Germany
TA  - Rontgenpraxis
JT  - Rontgenpraxis; Zeitschrift fur radiologische Technik
JID - 0404365
SB  - IM
MH  - Algorithms
MH  - Dose Fractionation, Radiation
MH  - Dose-Response Relationship, Radiation
MH  - Humans
MH  - Models, Theoretical
MH  - Neoplasms/*radiotherapy
MH  - Normal Distribution
MH  - *Radiotherapy Dosage
MH  - *Radiotherapy Planning, Computer-Assisted
EDAT- 2000/05/10 09:00
MHDA- 2000/06/10 09:00
CRDT- 2000/05/10 09:00
PHST- 2000/05/10 09:00 [pubmed]
PHST- 2000/06/10 09:00 [medline]
PHST- 2000/05/10 09:00 [entrez]
PST - ppublish
SO  - Rontgenpraxis. 2000;52(10-12):355-60.