PMID- 10804493
OWN - NLM
STAT- MEDLINE
DCOM- 20000712
LR  - 20041117
IS  - 0024-7758 (Print)
IS  - 0024-7758 (Linking)
VI  - 45
IP  - 4
DP  - 2000 Apr
TI  - Predicting asthma severity from allergic sensitivity to cockroaches in pregnant 
      inner city women.
PG  - 341-4
AB  - OBJECTIVE: To measure and compare cockroach (CR)-specific immunoglobin E (IgE) in 
      sera from pregnant women with mild, moderate and severe asthma. STUDY DESIGN: CR 
      IgE levels were measured in stored sera collected during the Collaborative 
      Perinatal Project. Three matched groups of 93 women were formed: group I (mild), 
      history of asthma but no acute exacerbation; group II (moderate), acute asthma 
      exacerbation; group III (severe), required hospitalization for a diagnosis of 
      status asthmaticus. ANOVA was used to compare the three means. RESULTS: Mean CR 
      IgE paralleled prenatal asthma severity. Mean values were 6.50, 13.12 and 28.99 
      kU/L for groups I, II and III, respectively (P = .06). High allergen sensitivity, 
      defined as CR IgE > 60 kU/L, was identified in 8 of the 93 study samples. The 
      prevalence of high allergen sensitivity increased as clinical asthma became more 
      severe. Sixty-two percent (5/8) of the high allergen sensitivity occurred in 
      group III. CONCLUSION: There appears to be a positive correlation between 
      sensitivity to CR allergens and asthma severity during pregnancy, and these 
      findings support further evaluation of CR allergen sensitivity as a predictor of 
      asthma severity in pregnancy.
FAU - Henderson, C E
AU  - Henderson CE
AD  - Department of Obstetrics and Gynecology and Women's Health, Albert Einstein 
      College of Medicine of Yeshiva University, Bronx, New York, USA.
FAU - Ownby, D R
AU  - Ownby DR
FAU - Trumble, A
AU  - Trumble A
FAU - DerSimonian, R
AU  - DerSimonian R
FAU - Kellner, L H
AU  - Kellner LH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Reprod Med
JT  - The Journal of reproductive medicine
JID - 0173343
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens
MH  - Animals
MH  - Asthma/*diagnosis/immunology
MH  - Cockroaches/*immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*classification/etiology
MH  - Immunoglobulin E/*analysis
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Pregnancy Complications/*immunology
MH  - Severity of Illness Index
MH  - Urban Population
EDAT- 2000/05/11 09:00
MHDA- 2000/07/15 11:00
CRDT- 2000/05/11 09:00
PHST- 2000/05/11 09:00 [pubmed]
PHST- 2000/07/15 11:00 [medline]
PHST- 2000/05/11 09:00 [entrez]
PST - ppublish
SO  - J Reprod Med. 2000 Apr;45(4):341-4.