PMID- 10805209
OWN - NLM
STAT- MEDLINE
DCOM- 20000802
LR  - 20081121
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 12
IP  - 4
DP  - 2000 Apr
TI  - Liver-infiltrating T lymphocytes are attracted selectively by IFN-inducible 
      protein-10.
PG  - 299-308
AB  - We have demonstrated that interferon-inducible protein-10 (IP-10) is produced in 
      hepatocytes surrounded by infiltrative mononuclear cells in chronic hepatitis. To 
      clarify the role of IP-10 in hepatitis, we examined the chemoattractive activity 
      of IP-10 on liver-infiltrating lymphocytes in experimental animal models of 
      hepatitis. IP-10 was specifically induced in the livers of mice treated 
      intravenously (i.v.) with Con A, while monocyte chemotactic protein-1 (MCP-1) 
      showed a much lower level of induction and neither RANTES nor macrophage 
      inflammatory protein-1alpha (MIP-1alpha) was detected. The liver-infiltrating 
      lymphocytes in Con A-induced hepatitis were attracted only by IP-10, and not by 
      other chemokines such as RANTES, MCP-1 and MIP-1alpha. The chemoattractive effect 
      of IP-10 was dose-dependent and was neutralized by monoclonal antibodies to 
      IP-10. The specific effect of IP-10 on liver-infiltrating lymphocytes was also 
      seen on those obtained from rat livers with fulminant hepatitis induced by 
      sequential treatment with killed Propionibacterium acnes (P. acnes) and LPS. 
      Peripheral blood lymphocytes were slightly attracted by IP-10 as well as RANTES 
      and MIP-1alpha, while hepatic resident lymphocytes were not. On the other hand, 
      thioglycolate-elicited peritoneal macrophages did not respond to IP-10, although 
      they did show a response to RANTES, MCP-1 and MIP-1alpha. These results indicated 
      that IP-10 is a specific chemoattractant for T lymphocytes in the inflammatory 
      liver tissues and may play a specific role in the development of hepatitis.
FAU - Tamaru, M
AU  - Tamaru M
AD  - Pharmaceutical Frontier Research Laboratories, JT Central Pharmaceutical Research 
      Institute, Yokohama, Kanagawa, Japan.
FAU - Nishioji, K
AU  - Nishioji K
FAU - Kobayashi, Y
AU  - Kobayashi Y
FAU - Watanabe, Y
AU  - Watanabe Y
FAU - Itoh, Y
AU  - Itoh Y
FAU - Okanoue, T
AU  - Okanoue T
FAU - Murai, M
AU  - Murai M
FAU - Matsushima, K
AU  - Matsushima K
FAU - Narumi, S
AU  - Narumi S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - COS Cells
MH  - Chemokine CXCL10
MH  - Chemokines, CXC/genetics/*immunology
MH  - Female
MH  - Hepatitis, Animal/*immunology
MH  - Humans
MH  - Interferon-gamma/immunology
MH  - Liver/*cytology/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Rats
MH  - Recombinant Fusion Proteins/genetics/immunology
MH  - T-Lymphocytes/*immunology
EDAT- 2000/05/11 09:00
MHDA- 2000/08/06 11:00
CRDT- 2000/05/11 09:00
PHST- 2000/05/11 09:00 [pubmed]
PHST- 2000/08/06 11:00 [medline]
PHST- 2000/05/11 09:00 [entrez]
AID - S1043-4666(99)90560-4 [pii]
AID - 10.1006/cyto.1999.0560 [doi]
PST - ppublish
SO  - Cytokine. 2000 Apr;12(4):299-308. doi: 10.1006/cyto.1999.0560.