PMID- 10805954
OWN - NLM
STAT- MEDLINE
DCOM- 20000621
LR  - 20211203
IS  - 8756-0437 (Print)
IS  - 1098-2388 (Linking)
VI  - 18
IP  - 4
DP  - 2000 Jun
TI  - Multiple endocrine neoplasias.
PG  - 324-32
AB  - Multiple endocrine neoplasia type 1 (MEN 1), and the multiple endocrine neoplasia 
      type 2 syndromes (MEN 2A, MEN 2B, and familial non-MEN medullary thyroid 
      carcinoma [FMTC]) encompass a wide range of endocrine problems, but arise from 
      only two genes: the MEN 1 tumor suppressor gene and the RET proto-oncogene. MEN 1 
      is characterized by parathyroid hyperplasia, pancreaticoduodenal neuroendocrine 
      tumors (PNTs), and pituitary adenomas. Surgery is the principal treatment 
      modality for hyperparathyroidism and PNTs, but questions still remain concerning 
      the timing and extent of surgery for PNTs. The MEN 2 syndromes are characterized 
      by complete penetrance of medullary thyroid cancer. The MEN 2 syndromes differ in 
      their variable expression of hyperparathyroidism, pheochromocytomas, and other 
      clinical features. Genetic testing for mutations in the RET gene has 
      revolutionized treatment by enabling thyroidectomies before significant disease 
      occurs.
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Phay, J E
AU  - Phay JE
AD  - Department of Surgery, Washington University School of Medicine, St. Louis, 
      Missouri, USA.
FAU - Moley, J F
AU  - Moley JF
FAU - Lairmore, T C
AU  - Lairmore TC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Surg Oncol
JT  - Seminars in surgical oncology
JID - 8503713
SB  - IM
MH  - Adenoma/*genetics/pathology/therapy
MH  - Carcinoma, Medullary/*genetics/pathology/therapy
MH  - Gene Expression Regulation, Neoplastic
MH  - Genes, Tumor Suppressor/genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Hyperparathyroidism/etiology
MH  - Multiple Endocrine Neoplasia/*genetics/pathology/therapy
MH  - Pheochromocytoma/etiology
MH  - Pituitary Neoplasms/*genetics/pathology/therapy
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogenes/genetics
MH  - Thyroid Gland/surgery
MH  - Thyroid Neoplasms/*genetics/pathology/therapy
RF  - 47
EDAT- 2000/05/11 09:00
MHDA- 2000/06/24 11:00
CRDT- 2000/05/11 09:00
PHST- 2000/05/11 09:00 [pubmed]
PHST- 2000/06/24 11:00 [medline]
PHST- 2000/05/11 09:00 [entrez]
AID - 10.1002/(SICI)1098-2388(200006)18:4<324::AID-SSU7>3.0.CO;2-5 [pii]
AID - 10.1002/(sici)1098-2388(200006)18:4<324::aid-ssu7>3.0.co;2-5 [doi]
PST - ppublish
SO  - Semin Surg Oncol. 2000 Jun;18(4):324-32. doi: 
      10.1002/(sici)1098-2388(200006)18:4<324::aid-ssu7>3.0.co;2-5.