PMID- 10806588
OWN - NLM
STAT- MEDLINE
DCOM- 20000710
LR  - 20190515
IS  - 1058-0468 (Print)
IS  - 1573-7330 (Electronic)
IS  - 1058-0468 (Linking)
VI  - 17
IP  - 2
DP  - 2000 Feb
TI  - Sex chromosomal analysis of spermatozoa from infertile men using fluorescence in 
      situ hybridization.
PG  - 97-102
AB  - PURPOSE: To confirm an association between male infertility and chromosome 
      aberrations of spermatozoa, we demonstrated the frequency of numerical 
      abnormalities of spermatozoa from infertile men with abnormal semen parameters 
      compared with fertile controls. METHOD: Sperm cells from 10 infertile patients 
      were investigated for disomy rates of sex chromosomes and chromosome 18 and 
      diploidy by fluorescence in situ hybridization (FISH). All patients showed 
      oligoasthenozoospermia with sperm counts 3-20 x 10(6)/ml and motile rates 0-40%. 
      RESULTS: Regarding XY disomy, a significantly higher frequency was found in 8 of 
      10 patients as compared to normal fertile men. The disomy rates of chromosome 18, 
      XX, YY, and diploidy rate were not increased. CONCLUSIONS: There is an 
      association between male infertility and embryo with aneuploidy of sex 
      chromosomes. Counseling about possible genetic risks should be provided to the 
      infertile couples planning assisted reproduction treatment.
FAU - Nishikawa, N
AU  - Nishikawa N
AD  - Department of Obstetrics and Gynecology, Nagoya City University Medical School, 
      Japan.
FAU - Murakami, I
AU  - Murakami I
FAU - Ikuta, K
AU  - Ikuta K
FAU - Suzumori, K
AU  - Suzumori K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Assist Reprod Genet
JT  - Journal of assisted reproduction and genetics
JID - 9206495
SB  - IM
MH  - Aneuploidy
MH  - Chromosome Aberrations/*genetics
MH  - Chromosome Disorders
MH  - Chromosomes, Human, Pair 18/ultrastructure
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Oligospermia/*genetics
MH  - Sex Chromosomes/*ultrastructure
MH  - Spermatozoa/*ultrastructure
PMC - PMC3455159
EDAT- 2000/05/12 09:00
MHDA- 2000/07/15 11:00
PMCR- 2001/02/01
CRDT- 2000/05/12 09:00
PHST- 2000/05/12 09:00 [pubmed]
PHST- 2000/07/15 11:00 [medline]
PHST- 2000/05/12 09:00 [entrez]
PHST- 2001/02/01 00:00 [pmc-release]
AID - 223488 [pii]
AID - 10.1023/a:1009413916753 [doi]
PST - ppublish
SO  - J Assist Reprod Genet. 2000 Feb;17(2):97-102. doi: 10.1023/a:1009413916753.