PMID- 10808148
OWN - NLM
STAT- MEDLINE
DCOM- 20000623
LR  - 20190921
IS  - 1053-2498 (Print)
IS  - 1053-2498 (Linking)
VI  - 19
IP  - 5
DP  - 2000 May
TI  - Prognostic value of serum cytokines in patients with congestive heart failure.
PG  - 419-25
AB  - BACKGROUND: Increased levels of circulating cytokines have been previously 
      reported in patients with congestive heart failure; however, whether they have 
      prognostic implications is still unknown. The aim of this study was to assess the 
      prognostic implications of elevated serum cytokines in patients with heart 
      failure and to identify the predictors of cytokine activation. METHODS AND 
      RESULTS: We assessed neurohormonal determinations, circulating cytokines, 
      ejection fraction (EF) and end-diastolic and end-systolic left ventricular 
      lengths in 87 patients (aged 57 +/- 9 years) with left ventricular dysfunction 
      (EF 24% +/- 6%). In 48 patients, we also assessed cytokine receptors. During 
      follow-up (mean, 14 +/- 9 months), 8 patients died and 12 had new heart failure 
      episodes that required hospital admission, 5 of whom underwent heart 
      transplantation. The univariate predictors of these events were serum 
      interleukin-6 (IL-6) (p = 0.00001), New York Heart Association (NYHA) functional 
      class (p = 0.0004), tumor necrosis factor-soluble receptor I (p = 0. 001), atrial 
      natriuretic peptide (p = 0.002), tumor necrosis factor-soluble receptor II (p = 
      0.004), angiotensin II (p = 0.006), serum interleukin-1 beta (p = 0.01), and 
      plasma renin activity (p = 0.02). Increased serum interleukin-6 (>10 pg/ml) was a 
      significant predictor of death or new heart failure episodes according to the 
      Kaplan-Meier survival method by log-rank test (p = 0.004). By Cox regression 
      analysis, serum IL-6 (p = 0.0005) and the NYHA functional class (p = 0.005) were 
      identified as independent predictors of prognosis. CONCLUSIONS: In patients with 
      congestive heart failure, increased serum IL-6 was identified as a powerful 
      independent predictor of the combined end point: death, new heart failure 
      episodes, and need for heart transplantation.
FAU - Orus, J
AU  - Orus J
AD  - Cardiovascular Institute, Hospital Clinic, University of Barcelona, Barcelona, 
      Spain.
FAU - Roig, E
AU  - Roig E
FAU - Perez-Villa, F
AU  - Perez-Villa F
FAU - Pare, C
AU  - Pare C
FAU - Azqueta, M
AU  - Azqueta M
FAU - Filella, X
AU  - Filella X
FAU - Heras, M
AU  - Heras M
FAU - Sanz, G
AU  - Sanz G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 11128-99-7 (Angiotensin II)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiotensin II/blood
MH  - Antigens, CD/blood
MH  - Atrial Natriuretic Factor/blood
MH  - Biomarkers/blood
MH  - Cytokines/*blood
MH  - Echocardiography, Doppler
MH  - Heart Failure/*blood/diagnostic imaging/mortality/surgery
MH  - Heart Transplantation
MH  - Humans
MH  - Interleukin-1/blood
MH  - Interleukin-6/blood
MH  - Middle Aged
MH  - Prognosis
MH  - Receptors, Cytokine/blood
MH  - Receptors, Tumor Necrosis Factor/blood
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Receptors, Tumor Necrosis Factor, Type II
MH  - Renin/blood
MH  - Survival Rate
EDAT- 2000/05/16 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/05/16 09:00
PHST- 2000/05/16 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/05/16 09:00 [entrez]
AID - S1053-2498(00)00083-8 [pii]
AID - 10.1016/s1053-2498(00)00083-8 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2000 May;19(5):419-25. doi: 
      10.1016/s1053-2498(00)00083-8.