PMID- 10809224
OWN - NLM
STAT- MEDLINE
DCOM- 20000627
LR  - 20191103
IS  - 1072-4109 (Print)
IS  - 1072-4109 (Linking)
VI  - 7
IP  - 3
DP  - 2000 May
TI  - Malignant rhabdoid tumor: A phenotype? An entity?--A controversy revisited.
PG  - 181-90
AB  - The term malignant rhabdoid tumor (MRT) has been used to describe a heterogeneous 
      group of neoplasms, having in common distinct so-called "rhabdoid" cytologic 
      features. The recent discovery of a candidate tumor suppressor gene for MRT, INI1 
      on chromosome (Ch)22q11.2, has re-established this neoplasm as a distinct entity. 
      Malignant rhabdoid tumor may arise either de novo from nonneoplastic cells or 
      through tumor progression from other types of neoplasms. These latter tumors, in 
      which other nonrhabdoid tumor components are identified, may be termed composite 
      MRT. In order to avoid misdiagnosing MRT as other types of neoplasia, one must 
      keep in mind three distinct clinicopathologic features--young age of onset, 
      variable histologic and immunohistochemical patterns, and an aggressive 
      infiltrative character. In difficult cases, cytogenetics, fluorescence in situ 
      hybridization (FISH), and molecular genetic analysis may assist in diagnosing 
      MRT.
FAU - Ogino, S
AU  - Ogino S
AD  - Department of Pathology, Hospital of the University of Pennsylvania, 
      Philadelphia, USA.
FAU - Ro, T Y
AU  - Ro TY
FAU - Redline, R W
AU  - Redline RW
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Anat Pathol
JT  - Advances in anatomic pathology
JID - 9435676
RN  - 0 (Vimentin)
RN  - 68238-35-7 (Keratins)
SB  - IM
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Keratins/metabolism
MH  - Kidney Neoplasms/*diagnosis
MH  - Neoplasm Invasiveness
MH  - Rhabdoid Tumor/*diagnosis/genetics/metabolism/pathology
MH  - Rhabdomyosarcoma/*diagnosis/genetics/metabolism/pathology
MH  - Vimentin/metabolism
RF  - 74
EDAT- 2000/05/16 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/05/16 09:00
PHST- 2000/05/16 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/05/16 09:00 [entrez]
AID - 10.1097/00125480-200007030-00007 [doi]
PST - ppublish
SO  - Adv Anat Pathol. 2000 May;7(3):181-90. doi: 10.1097/00125480-200007030-00007.