PMID- 10810246
OWN - NLM
STAT- MEDLINE
DCOM- 20000711
LR  - 20190607
IS  - 1021-7770 (Print)
IS  - 1021-7770 (Linking)
VI  - 7
IP  - 3
DP  - 2000 May-Jun
TI  - Acute cross-tolerance to opioids in heroin delta-opioid-responding Swiss Webster 
      mice.
PG  - 258-69
AB  - It is generally thought that the mu receptor actions of metabolites, 
      6-monoacetylmorphine (6MAM) and morphine, account for the pharmacological actions 
      of heroin. However, upon intracerebroventricular (i.c.v.) administration in Swiss 
      Webster mice, heroin and 6MAM act on delta receptors while morphine acts on mu 
      receptors. Swiss Webster mice made tolerant to subcutaneous (s.c.) morphine by 
      morphine pellet were not cross-tolerant to s.c. heroin (at 20 min in the tail 
      flick test). Now, opioids were given in combination, s.c. (6.5 h) and i.c.v. (3 
      h) preceding testing the challenging agonist i.c.v. (at 10 min in the tail flick 
      test). The combination (s.c. + i.c.v.) morphine pretreatment induced tolerance to 
      the mu action of morphine but no cross-tolerance to the delta action of heroin, 
      6MAM and DPDPE and explained why morphine pelleting did not produce 
      cross-tolerance to s.c. heroin above. Heroin plus heroin produced tolerance to 
      delta agonists but not to mu agonists. Surprisingly, all combinations of morphine 
      with the delta agonists produced tolerance to morphine which now acted through 
      delta receptors (inhibited by i.c.v. naltrindole), an unusual change in receptor 
      selectivity for morphine.
FAU - Rady, J J
AU  - Rady JJ
AD  - Research Service, Clement J. Zablocki Veterans Affairs Medical Center and Medical 
      College of Wisconsin, Milwaukee, Wisc., USA.
FAU - Fujimoto, J M
AU  - Fujimoto JM
LA  - eng
GR  - DA00451/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Biomed Sci
JT  - Journal of biomedical science
JID - 9421567
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Drug Implants)
RN  - 0 (Morphine Derivatives)
RN  - 0 (Narcotics)
RN  - 0 (Receptors, Opioid, delta)
RN  - 0 (Receptors, Opioid, mu)
RN  - 100929-53-1 (Enkephalin, Ala(2)-MePhe(4)-Gly(5)-)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 5S6W795CQM (Naltrexone)
RN  - 70D95007SX (Heroin)
RN  - 76I7G6D29C (Morphine)
RN  - 88373-73-3 (Enkephalin, D-Penicillamine (2,5)-)
RN  - G167Z38QA4 (naltrindole)
RN  - M5E47P1ZCH (6-O-monoacetylmorphine)
SB  - IM
MH  - Analgesics, Opioid/pharmacology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Cross Reactions
MH  - Drug Implants/administration & dosage
MH  - Drug Tolerance/*physiology
MH  - Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology
MH  - Enkephalin, D-Penicillamine (2,5)-/pharmacology
MH  - Heroin/*pharmacology
MH  - Injections, Intraventricular
MH  - Injections, Subcutaneous
MH  - Male
MH  - Mice
MH  - Morphine/administration & dosage/pharmacology
MH  - Morphine Derivatives/pharmacology
MH  - Naltrexone/analogs & derivatives/pharmacology
MH  - Narcotics/*pharmacology
MH  - Pain Measurement
MH  - Receptors, Opioid, delta/agonists/*drug effects/physiology
MH  - Receptors, Opioid, mu/agonists/*drug effects/physiology
MH  - Sodium Chloride/pharmacology
MH  - Time Factors
EDAT- 2000/05/16 09:00
MHDA- 2000/07/15 11:00
CRDT- 2000/05/16 09:00
PHST- 2000/05/16 09:00 [pubmed]
PHST- 2000/07/15 11:00 [medline]
PHST- 2000/05/16 09:00 [entrez]
AID - 25457 [pii]
AID - 10.1007/BF02255475 [doi]
PST - ppublish
SO  - J Biomed Sci. 2000 May-Jun;7(3):258-69. doi: 10.1007/BF02255475.