PMID- 10810421
OWN - NLM
STAT- MEDLINE
DCOM- 20000531
LR  - 20221207
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 20
IP  - 2B
DP  - 2000 Mar-Apr
TI  - Diagnosis and survey of abnormal/atypical squamous cells of undetermined 
      significance and low-grade squamous intraepithelial lesions: a retrospective 
      study.
PG  - 1195-9
AB  - The new Bethesda System (BS) terminology has opened a series of problems about 
      the Abnormal/Atypical Squamous Cells of Undetermined Significance (ASCUS) and 
      Low-Grade Squamous Intraepithelial Lesion (L-SIL) categories, particularly on 
      their treatment and follow-up. Moreover in these field a non negligible portion 
      of lesions progress to High-Grade Lesion (H-SIL). With the aim of comparing the 
      data, we examined samples observed in our Ambulatories with 6-12 months 
      follow-up. We observed retrospectively 11.197 Pap test from January 1995 to June 
      1997, mostly first visits. All received a Pap test, colposcopy and gynaecological 
      examination. Biopsy and histological standard examinations were performed when 
      necessary. Alterations classified as mild epithelial abnormalities, of both ASCUS 
      and L-SIL categories, were observed in 146 cases: 78 ASCUS and 68 L-SIL. Of these 
      48 were CIN 1/mild dysplasia (25 HPV associated) and 20 were HPV lesions, 
      according to BS. All the cases with persistent ASCUS and L-SIL underwent a second 
      control. In these 45 cases we observed 2 new cases of H-SIL and one of L-SIL; so 
      82.3% and 30.7% of ASCUS and L-SIL regressed to negatives. In the stable group 
      11.8% and 60.4% were ASCUS and L-SIL. Moreover 5.9% of ASCUS and 4.8% of L-SIL 
      progressed to H-SIL. No cases of invasive cancer were observed. Our data show 
      that ASCUS and L-SIL diagnosis can identify 6% and 4.8% of H-SIL respectively. In 
      addition 17-18% of ASCUS were stable or progressed. These two categories, as 
      already demonstrated in other studies, are mostly at risk.
FAU - Giudice, A
AU  - Giudice A
AD  - IST (Istituto Nazionale per la Ricerca sul Cancro) Genova, Sez. Dec. Messina, 
      Italy.
FAU - Rizzo, M
AU  - Rizzo M
FAU - Rossi, R T
AU  - Rossi RT
FAU - Bonaffini, O
AU  - Bonaffini O
FAU - Buda, C A
AU  - Buda CA
FAU - Pettineo, G
AU  - Pettineo G
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Cervix Uteri/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Retrospective Studies
MH  - Time Factors
MH  - Uterine Cervical Neoplasms/classification/*pathology
MH  - Vaginal Smears
MH  - Uterine Cervical Dysplasia/classification/*pathology
EDAT- 2000/05/16 09:00
MHDA- 2000/06/03 09:00
CRDT- 2000/05/16 09:00
PHST- 2000/05/16 09:00 [pubmed]
PHST- 2000/06/03 09:00 [medline]
PHST- 2000/05/16 09:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2000 Mar-Apr;20(2B):1195-9.