PMID- 10812174
OWN - NLM
STAT- MEDLINE
DCOM- 20000608
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 119
IP  - 1
DP  - 2000 May
TI  - Spurious monosomy 7 in leukemia due to centromeric heteromorphism.
PG  - 67-9
AB  - We report heteromorphism of the centrometric region of human chromosome 7, which 
      was observed in the cytogenetic assessment of a complete remission of a pre-B 
      acute lymphoblastic leukemia in the bone marrow cells of a 25-year-old woman. 
      Classical cytogenetic study was performed, as well as metaphase and interphase 
      fluorescence in situ hybridization (FISH) carried out with an alphoid DNA probe 
      specific for the chromosome 7 centromere for detection of leukemic clones with 
      monosomy 7 found at the initial diagnosis. We show an important centromeric 
      heteromorphism of this chromosome detected by FISH and clearly visible on all 
      metaphases and nuclei analyzed. This heteromorphism is observable as a 
      fluorescent signal five- or sixfold larger than that on the homologue. To our 
      knowledge, this heteromorphism of chromosome 7 has not been reported in the 
      literature. However, with the use of FISH analysis, it could be easily mistaken 
      for a mosaicism of monosomy 7, which can be misleading in the interpretation of 
      the results.
FAU - Duval, A
AU  - Duval A
AD  - Laboratoire d'Hematologie, Immunologie, et Cytogenetique, Hopital Kremlin 
      Bicetre, Villejuif, France.
FAU - Feneux, D
AU  - Feneux D
FAU - Sutton, L
AU  - Sutton L
FAU - Tchernia, G
AU  - Tchernia G
FAU - Leonard, C
AU  - Leonard C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
CIN - Cancer Genet Cytogenet. 2000 Dec;123(2):144. PMID: 11156446
MH  - Adult
MH  - Bone Marrow Transplantation
MH  - Burkitt Lymphoma/drug therapy/*genetics/therapy
MH  - *Centromere
MH  - *Chromosomes, Human, Pair 7
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - *Monosomy
EDAT- 2000/05/17 09:00
MHDA- 2000/06/10 09:00
CRDT- 2000/05/17 09:00
PHST- 2000/05/17 09:00 [pubmed]
PHST- 2000/06/10 09:00 [medline]
PHST- 2000/05/17 09:00 [entrez]
AID - S0165-4608(99)00204-6 [pii]
AID - 10.1016/s0165-4608(99)00204-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 May;119(1):67-9. doi: 10.1016/s0165-4608(99)00204-6.