PMID- 10813321
OWN - NLM
STAT- MEDLINE
DCOM- 20000714
LR  - 20161124
IS  - 0022-3468 (Print)
IS  - 0022-3468 (Linking)
VI  - 35
IP  - 5
DP  - 2000 May
TI  - Local staging of Wilms' tumor--computerized tomography correlation with 
      histological findings.
PG  - 677-9
AB  - PURPOSE: The aim of this study was to assess the accuracy of computed tomography 
      (CT) in the local staging of Wilms' tumor. METHODS: Twenty-six patients with 
      unilateral, nonmetastatic Wilms' tumors were accrued over the period of 1990 
      through 1997. Preoperative CT staging was performed before surgical biopsy or 
      excision. The abdominal CT images were reviewed and staged for local disease 
      according to National Wilms' Tumour Study (NWTS) Group Staging V as either 
      intrarenal disease (Stage I), local extrarenal extension amenable to complete 
      local excision (Stage II), or advanced local disease (Stage III). Patients with 
      metastatic (Stage IV) and bilateral disease (Stage V) were excluded from our 
      study. Results were compared to histological findings. RESULTS: CT scan correctly 
      staged 10 of 26 cases (38%) of Wilms' tumor. CT scan overstaged 12 of 16 (75%) 
      localized renal disease (Stage I) and local extension (Stage II) tumors, and 
      understaged 4 of 10 (40%) localized spread (Stage III) tumors. CONCLUSIONS: CT 
      scan appears to have poor correlation to histological staging. Therefore, basing 
      therapy solely on radiological imaging may lead to some patients receiving more 
      intense therapy than necessary, whereas others do not receive sufficient 
      therapeutic regimens. Histological assessment of the excised mass should remain 
      the standard for staging Wilms' tumors.
FAU - Gow, K W
AU  - Gow KW
AD  - Department of Surgery, Radiology, and Pathology, British Columbia's Children's 
      Hospital and the University of British Columbia, Vancouver, Canada.
FAU - Roberts, I F
AU  - Roberts IF
FAU - Jamieson, D H
AU  - Jamieson DH
FAU - Bray, H
AU  - Bray H
FAU - Magee, J F
AU  - Magee JF
FAU - Murphy, J J
AU  - Murphy JJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/administration & dosage
MH  - Biopsy, Needle
MH  - Child
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Kidney Neoplasms/*diagnostic imaging/*pathology/therapy
MH  - Male
MH  - Neoplasm Staging
MH  - Nephrectomy
MH  - Preoperative Care
MH  - Prognosis
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - *Tomography, X-Ray Computed
MH  - Wilms Tumor/*diagnostic imaging/*pathology/therapy
EDAT- 2000/05/17 09:00
MHDA- 2000/07/25 11:00
CRDT- 2000/05/17 09:00
PHST- 2000/05/17 09:00 [pubmed]
PHST- 2000/07/25 11:00 [medline]
PHST- 2000/05/17 09:00 [entrez]
AID - S0022-3468(00)30331-1 [pii]
AID - 10.1053/jpsu.2000.5941 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2000 May;35(5):677-9. doi: 10.1053/jpsu.2000.5941.