PMID- 10816306
OWN - NLM
STAT- MEDLINE
DCOM- 20000713
LR  - 20220129
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 3
IP  - 6
DP  - 2000 Jun
TI  - Rapid and selective induction of BDNF expression in the hippocampus during 
      contextual learning.
PG  - 533-5
AB  - The hippocampus is required for many forms of long-term memory in both humans and 
      animals, and formation of long-lasting memories requires the synthesis of new 
      proteins. Furthermore, the long-term potentiation (LTP) of hippocampal synapses, 
      a widely studied model of memory, also depends on both de novo gene transcription 
      and protein synthesis and results in the activation of transcription from 
      promotors containing the cAMP response element (CRE). Expression of several genes 
      is induced during the establishment of LTP; these include the immediate-early 
      genes (IEGs) BDNF (brain-derived neurotrophic factor), zif268 and C/EBPbeta 
      (CCAAT-enhancer binding protein beta), all of which contain CRE sites within 
      their promotor regions. However, these genes induced by LTP are not known to be 
      rapidly induced following learning in a natural setting. Here we demonstrate 
      rapid and selective induction of BDNF expression during hippocampus-dependent 
      contextual learning.
FAU - Hall, J
AU  - Hall J
AD  - Department of Experimental Psychology, University of Cambridge, Downing Site, 
      Tennis Court Road, Cambridge CB2 3EB, UK.
FAU - Thomas, K L
AU  - Thomas KL
FAU - Everitt, B J
AU  - Everitt BJ
LA  - eng
GR  - G9537855/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (CCAAT-Enhancer-Binding Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (Egr1 protein, rat)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amygdala/metabolism
MH  - Animals
MH  - Autoradiography
MH  - Avoidance Learning/*physiology
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/genetics
MH  - CCAAT-Enhancer-Binding Proteins
MH  - Conditioning, Psychological/physiology
MH  - DNA-Binding Proteins/biosynthesis/genetics
MH  - Discrimination Learning/*physiology
MH  - Early Growth Response Protein 1
MH  - Gene Expression
MH  - Hippocampus/*metabolism
MH  - *Immediate-Early Proteins
MH  - Inhibition, Psychological
MH  - Long-Term Potentiation/physiology
MH  - Nuclear Proteins/biosynthesis/genetics
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Transcription Factors/biosynthesis/genetics
EDAT- 2000/05/18 09:00
MHDA- 2000/07/15 11:00
CRDT- 2000/05/18 09:00
PHST- 2000/05/18 09:00 [pubmed]
PHST- 2000/07/15 11:00 [medline]
PHST- 2000/05/18 09:00 [entrez]
AID - 10.1038/75698 [doi]
PST - ppublish
SO  - Nat Neurosci. 2000 Jun;3(6):533-5. doi: 10.1038/75698.