PMID- 10817624
OWN - NLM
STAT- MEDLINE
DCOM- 20000717
LR  - 20220408
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 11
IP  - 6
DP  - 2000 Apr 27
TI  - Mapping the differences in the brain concentration of brain-derived neurotrophic 
      factor (BDNF) and nerve growth factor (NGF) in an animal model of depression.
PG  - 1369-73
AB  - Antidepressant drugs as well as electroconvulsive stimuli can significantly 
      influence brain concentrations of neurotrophic factors. However, it is not known 
      whether the baseline brain concentrations of neurotrophic factors are altered in 
      human subjects suffering from affective disorders or whether there are sex 
      differences in concentrations of neurotrophins in human brain. In order to 
      elucidate some of these questions, we measured by ELISA brain-derived 
      neurotrophic factor (BDNF) and nerve growth factor (NGF) in an animal model of 
      depression, the Flinders Sensitive Line (FSL) rats and their controls, the 
      Flinders Resistant Line (FRL). Altered BDNF and NGF concentrations were found in 
      frontal cortex, occipital cortex, and hypothalamus of depressed FSL compared to 
      FRL control rats. Furthermore, different levels of these neurotrophins were also 
      found in the male and female brain. Cumulatively these observations suggest that 
      BDNF and NGF may play a role in depression and, hypothetically, different brain 
      regional concentrations of BDNF and NGF in male and female animals may be 
      relevant to gender differences in vulnerability to depression.
FAU - Angelucci, F
AU  - Angelucci F
AD  - Karolinska Institutet, Department of Clinical Neuroscience, St Goran's Hospital, 
      Stockholm, Sweden.
FAU - Aloe, L
AU  - Aloe L
FAU - Vasquez, P J
AU  - Vasquez PJ
FAU - Mathe, A A
AU  - Mathe AA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism/pathology
MH  - Brain Chemistry/genetics
MH  - Brain-Derived Neurotrophic Factor/*analysis
MH  - Corpus Striatum/chemistry/metabolism
MH  - Depression/*metabolism
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Frontal Lobe/chemistry/metabolism
MH  - Hypothalamus/chemistry/metabolism
MH  - In Vitro Techniques
MH  - Male
MH  - Nerve Growth Factor/*analysis
MH  - Occipital Lobe/chemistry/metabolism
MH  - Organ Size
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sex Factors
EDAT- 2000/05/19 09:00
MHDA- 2000/07/25 11:00
CRDT- 2000/05/19 09:00
PHST- 2000/05/19 09:00 [pubmed]
PHST- 2000/07/25 11:00 [medline]
PHST- 2000/05/19 09:00 [entrez]
AID - 10.1097/00001756-200004270-00044 [doi]
PST - ppublish
SO  - Neuroreport. 2000 Apr 27;11(6):1369-73. doi: 10.1097/00001756-200004270-00044.