PMID- 10817775
OWN - NLM
STAT- MEDLINE
DCOM- 20000628
LR  - 20190513
IS  - 1462-0324 (Print)
IS  - 1462-0324 (Linking)
VI  - 39
IP  - 4
DP  - 2000 Apr
TI  - Prevalence of rheumatic manifestations and antineutrophil cytoplasmic antibodies 
      in haematological malignancies. A prospective study.
PG  - 417-20
AB  - OBJECTIVE: To evaluate the prevalence of antineutrophil cytoplasmic antibodies 
      (ANCA) and rheumatic manifestations associated with chronic haematological 
      malignancies. METHODS: Two groups of patients were prospectively studied (group 
      I: 60 patients with myelodysplastic syndromes and group II: 140 patients with 
      lymphoid malignancies) for clinical 'immune' manifestations and ANCA. RESULTS: In 
      the myelodysplastic group, six patients had ANCA-negative systemic medium-size 
      vasculitis, one had systemic vasculitis with cytoplasmic ANCA, one relapsing 
      polychondritis, one giant cell arteritis, one polymyalgia rheumatica, one 
      polyarthritis and two fasciitis. In group II, two patients had ANCA-negative 
      systemic vasculitis, two had leucocytoclastic vasculitis associated with 
      tuberculosis, two had polyarthritis, one polymyalgia rheumatica and one giant 
      cell arteritis. Six sera were ANCA-positive with perinuclear pattern in four 
      cases, atypical pattern in one and cytoplasmic pattern in one. Two sera had 
      anti-myeloperoxidase (MPO) specificity, and others had no known specificity; none 
      had anti-proteinase 3 (PR3) specificity. Global prevalence of ANCA in our cohort 
      was 3%, similar to the French general population. CONCLUSION: Polyarteritis 
      nodosa-type systemic vasculitis and polymyalgia rheumatica were the most frequent 
      findings (18%) in myelodysplastic syndromes and particularly in chronic 
      myelomonocytic leukaemia. ANCA were not helpful for the diagnosis of vasculitis. 
      Vasculitis associated with infection, in particular tuberculosis, must be ruled 
      out.
FAU - Hamidou, M A
AU  - Hamidou MA
AD  - Department of Internal Medicine, University Hospital, Hotel-Dieu, 44093 Nantes, 
      France.
FAU - Derenne, S
AU  - Derenne S
FAU - Audrain, M A
AU  - Audrain MA
FAU - Berthelot, J M
AU  - Berthelot JM
FAU - Boumalassa, A
AU  - Boumalassa A
FAU - Grolleau, J Y
AU  - Grolleau JY
LA  - eng
PT  - Journal Article
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Antineutrophil Cytoplasmic/*analysis/immunology
MH  - Female
MH  - Hematologic Neoplasms/*complications/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/complications
MH  - Polymyalgia Rheumatica/etiology
MH  - Prevalence
MH  - Prospective Studies
MH  - Rheumatic Diseases/epidemiology/*etiology
MH  - Vasculitis/epidemiology/*etiology
EDAT- 2000/05/19 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/05/19 09:00
PHST- 2000/05/19 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/05/19 09:00 [entrez]
AID - 10.1093/rheumatology/39.4.417 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2000 Apr;39(4):417-20. doi: 10.1093/rheumatology/39.4.417.