PMID- 1081865
OWN - NLM
STAT- MEDLINE
DCOM- 19760209
LR  - 20080317
IS  - 0003-987X (Print)
IS  - 0003-987X (Linking)
VI  - 111
IP  - 11
DP  - 1975 Nov
TI  - Discoid lupus erythematosus as part of a larger disease spectrum. Correlation of 
      clinical features with laboratory findings in lupus erythematosus.
PG  - 1448-52
AB  - This study compares the immunologic features of a homogeneous group of patients 
      with discoid lupus erythematosus (DLE) strictly limited to the skin (group 1) 
      with those of patients with active discoid skin lesions plus visceral involvement 
      (group 2) and with those of lupus erythematosus (LE) patients with proliferative 
      glomerulonephritis (group 3). Positive antinuclear antibody (ANA) was found in 4% 
      of group 1, 93% of group 2, and 100% of group 3. Low total hemolytic complement 
      (CH50) was found in 4% of group 1, 47% of group 2, and 100% of group 3. 
      Antibodies to native DNA (nDNA) were not found in group 1, were rarely found in 
      group 2, and were present in nearly all patients in group 3. No group 1 patient 
      had subepidermal immunoglobulin deposits in normal skin, 20% of group 2 had this 
      finding, and 100% of group 3 had this finding. The ability to develop chronic 
      discoid skin lesions appears to be associated with a reduced incidence of 
      immunologic parameters of disease activity. The data suggest that patients with 
      active discoid skin lesions rarely have severe renal disease.
FAU - Prystowsky, S D
AU  - Prystowsky SD
FAU - Gilliam, J N
AU  - Gilliam JN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Histocompatibility Antigens)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Antibodies, Antinuclear/analysis
MH  - *Antibody Formation
MH  - DNA/immunology
MH  - Glomerulonephritis/complications
MH  - Histocompatibility Antigens/*analysis
MH  - Humans
MH  - *Immunity, Cellular
MH  - Lupus Erythematosus, Discoid/complications/*immunology
MH  - Skin/immunology
EDAT- 1975/11/01 00:00
MHDA- 1975/11/01 00:01
CRDT- 1975/11/01 00:00
PHST- 1975/11/01 00:00 [pubmed]
PHST- 1975/11/01 00:01 [medline]
PHST- 1975/11/01 00:00 [entrez]
PST - ppublish
SO  - Arch Dermatol. 1975 Nov;111(11):1448-52.