PMID- 10819905
OWN - NLM
STAT- MEDLINE
DCOM- 20000606
LR  - 20141120
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 36
IP  - 4
DP  - 2000 Jun 15
TI  - Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or 
      dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia 
      nigra pars reticulata, and the dorsal raphe nucleus slices.
PG  - 275-85
AB  - We examined the effects of pressure ejected 3, 4-methylenedioxymethamphetamine 
      (MDMA) from a micropipette on direct chemically stimulated release, and on 
      electrically stimulated serotonin (5-HT) or dopamine (DA) release in the caudate 
      putamen (CPu), nucleus accumbens (NAc), substantia nigra pars reticulata (SNr), 
      and the dorsal raphe nucleus (DRN) brain slices of rat, using fast cyclic 
      voltammetry (FCV). MDMA is electroactive, oxidising at +1100 mV. When the anodic 
      input waveform was reduced from +1.4 to +1.0 volt, MDMA was not electroactive. 
      Using this waveform, pressure ejection of MDMA did not release 5-HT or DA in 
      brain slices prepared from any of the nuclei studied. MDMA significantly 
      potentiated electrically stimulated 5-HT release in the SNr and DA release in 
      CPu. In the DRN or in the NAc, MDMA was without effect on peak electrically 
      stimulated 5-HT or DA release. The rates of neurotransmitter uptake, expressed as 
      t(1/2), were in all cases significantly decreased after MDMA. The results 
      indicate that MDMA, unlike (+)amphetamine, is not as a releaser of DA or 5-HT, it 
      is a potent inhibitor of both DA and 5-HT uptake.
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Iravani, M M
AU  - Iravani MM
AD  - Department of Pharmacology, Queen Mary & Westfield College, University of London, 
      UK. m.iravani@kcl.ac.uk
FAU - Asari, D
AU  - Asari D
FAU - Patel, J
AU  - Patel J
FAU - Wieczorek, W J
AU  - Wieczorek WJ
FAU - Kruk, Z L
AU  - Kruk ZL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 333DO1RDJY (Serotonin)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Amphetamine/pharmacology
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Caudate Nucleus/metabolism
MH  - Dopamine/*metabolism
MH  - Electric Stimulation
MH  - Electrochemistry
MH  - In Vitro Techniques
MH  - Injections, Jet
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Nucleus Accumbens/metabolism
MH  - Raphe Nuclei/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/*metabolism
MH  - Substantia Nigra/metabolism
EDAT- 2000/05/20 09:00
MHDA- 2000/06/10 09:00
CRDT- 2000/05/20 09:00
PHST- 2000/05/20 09:00 [pubmed]
PHST- 2000/06/10 09:00 [medline]
PHST- 2000/05/20 09:00 [entrez]
AID - 10.1002/(SICI)1098-2396(20000615)36:4<275::AID-SYN4>3.0.CO;2-# [pii]
AID - 10.1002/(SICI)1098-2396(20000615)36:4<275::AID-SYN4>3.0.CO;2-# [doi]
PST - ppublish
SO  - Synapse. 2000 Jun 15;36(4):275-85. doi: 
      10.1002/(SICI)1098-2396(20000615)36:4<275::AID-SYN4>3.0.CO;2-#.