PMID- 10821958
OWN - NLM
STAT- MEDLINE
DCOM- 20000720
LR  - 20191103
IS  - 0167-5877 (Print)
IS  - 0167-5877 (Linking)
VI  - 45
IP  - 3-4
DP  - 2000 Jun 12
TI  - A discrete-event computer model of feline herpes virus within cat populations.
PG  - 163-81
AB  - The purpose of this work was to study the epidemiology of feline herpes virus 
      (FHV), which causes a respiratory disease within natural populations of domestic 
      cats. A stochastic model was constructed using discrete-events simulation. Two 
      habitats (rural vs. urban) were simulated, featuring different demographic, 
      spatial and social patterns. The evolution of immunity in individuals was 
      reproduced, allowing for the random recrudescence of latent infections 
      (influenced by environment and reproduction). Hypotheses concerning the 
      circulation of FHV were examined regarding the role of host density and the 
      possibility of reinfection of host. Uncertainty analyses were performed on the 
      basis of replicated Monte Carlo sampling. The results were in good agreement with 
      serologic data from a long-term study conducted on five populations in France. 
      The model satisfactorily reproduced the variability of natural immunity, and the 
      epidemic features observed. The simulations have shown that FHV can persist in 
      small populations (because of its capacity of reactivation leading to epidemics). 
      However, the impact on demography was not dramatic. The most important parameters 
      in determining change in epidemiology of FHV were: transmission rate 
      corresponding to 'friendly' contacts, and the recrudescence rate of FHV. However, 
      an interaction between these two parameters did not allow estimation of their 
      values.
FAU - Cohen, C
AU  - Cohen C
AD  - Berne University and Monitoring Group, Federal Veterinary Office, Bern, 
      Switzerland. carine.cohen@bvet.admin.ch
FAU - Artois, M
AU  - Artois M
FAU - Pontier, D
AU  - Pontier D
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Prev Vet Med
JT  - Preventive veterinary medicine
JID - 8217463
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
SB  - IM
MH  - Animals
MH  - Animals, Domestic
MH  - Animals, Wild
MH  - Antibodies, Viral/blood
MH  - Antigens, Viral/blood
MH  - Cat Diseases/*epidemiology/transmission/virology
MH  - Cats
MH  - *Computer Simulation
MH  - Disease Outbreaks/veterinary
MH  - Female
MH  - France/epidemiology
MH  - Herpesviridae Infections/epidemiology/*veterinary/virology
MH  - Male
MH  - *Models, Biological
MH  - Monte Carlo Method
MH  - Population Density
MH  - Recurrence
MH  - Regression Analysis
MH  - Respiratory Tract Infections/epidemiology/*veterinary/virology
MH  - Risk Factors
MH  - Varicellovirus/*immunology/isolation & purification
EDAT- 2000/05/24 09:00
MHDA- 2000/07/25 11:00
CRDT- 2000/05/24 09:00
PHST- 2000/05/24 09:00 [pubmed]
PHST- 2000/07/25 11:00 [medline]
PHST- 2000/05/24 09:00 [entrez]
AID - S0167-5877(00)00132-X [pii]
AID - 10.1016/s0167-5877(00)00132-x [doi]
PST - ppublish
SO  - Prev Vet Med. 2000 Jun 12;45(3-4):163-81. doi: 10.1016/s0167-5877(00)00132-x.