PMID- 10822049
OWN - NLM
STAT- MEDLINE
DCOM- 20000801
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 396
IP  - 1
DP  - 2000 May 12
TI  - Different effects of NMDA/group I metabotropic glutamate receptor agents in 
      delta- and mu-opioid receptor agonist-induced supraspinal antinociception.
PG  - 23-8
AB  - The N-methyl-D-aspartate (NMDA) and metabotropic glutamate (mGlu) receptors are 
      involved in nociceptive transmission in the central nervous system. The present 
      study was designed to study the effects of NMDA and group I mGlu receptor agents 
      on delta- and mu-opioid receptor agonist-induced antinociception in the mouse 
      brain. Intracerebroventricular (i.c.v.) treatment with the non-competitive NMDA 
      receptor antagonist dizocilpine and the group I mGlu receptor antagonist 
      (S)-4-carboxyphenylglycine ((S)-4CPG) significantly attenuated the 
      antinociception induced by the delta-opioid receptor agonists [D-Pen(2), 
      Pen(5)]enkephalin (DPDPE), (-)-TAN 67 and [D-Ala(2)]deltorphin II. On the 
      contrary, i.c.v. administration of dizocilpine and (S)-4CPG slightly but 
      significantly enhanced the antinociception induced by the mu-opioid receptor 
      agonist [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]enkephalin (DAMGO). Under these 
      conditions, i.c.v. administration of NMDA and the group I mGlu receptor agonist 
      3,5-dihydrophenylglycine (DHPG) significantly enhanced the antinociception 
      induced by delta-opioid receptor agonists, whereas both reduced DAMGO-induced 
      antinociception. These findings suggest that the supraspinal antinociceptive 
      actions of mu- and delta-opioid receptor agonists appear to be modulated 
      differently by NMDA and group I mGlu receptors in the mouse.
FAU - Suzuki, T
AU  - Suzuki T
AD  - Department of Toxicology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, 
      Shinagawa-ku, 142-8501, Tokyo, Japan. suzuki@hoshi.ac.jp
FAU - Aoki, T
AU  - Aoki T
FAU - Ohnishi, O
AU  - Ohnishi O
FAU - Nagase, H
AU  - Nagase H
FAU - Narita, M
AU  - Narita M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Analgesics)
RN  - 0 (Benzoates)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Oligopeptides)
RN  - 0 (Quinolines)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Receptors, Opioid, delta)
RN  - 0 (Receptors, Opioid, mu)
RN  - 0 (TAN 67)
RN  - 100929-53-1 (Enkephalin, Ala(2)-MePhe(4)-Gly(5)-)
RN  - 122752-16-3 (deltorphin II, Ala(2)-)
RN  - 7292-81-1 (4-carboxyphenylglycine)
RN  - 88373-73-3 (Enkephalin, D-Penicillamine (2,5)-)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Analgesics/administration & dosage/*pharmacology
MH  - Animals
MH  - Benzoates/pharmacology
MH  - Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology
MH  - Enkephalin, D-Penicillamine (2,5)-/pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Glycine/analogs & derivatives/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Oligopeptides/pharmacology
MH  - Pain Measurement/drug effects
MH  - Quinolines/pharmacology
MH  - Receptors, Metabotropic Glutamate/*drug effects
MH  - Receptors, N-Methyl-D-Aspartate/*drug effects
MH  - Receptors, Opioid, delta/*agonists
MH  - Receptors, Opioid, mu/*agonists
EDAT- 2000/05/24 09:00
MHDA- 2000/08/06 11:00
CRDT- 2000/05/24 09:00
PHST- 2000/05/24 09:00 [pubmed]
PHST- 2000/08/06 11:00 [medline]
PHST- 2000/05/24 09:00 [entrez]
AID - S0014-2999(00)00183-7 [pii]
AID - 10.1016/s0014-2999(00)00183-7 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2000 May 12;396(1):23-8. doi: 10.1016/s0014-2999(00)00183-7.