PMID- 10822240
OWN - NLM
STAT- MEDLINE
DCOM- 20000802
LR  - 20191103
IS  - 0885-6230 (Print)
IS  - 0885-6230 (Linking)
VI  - 15
IP  - 5
DP  - 2000 May
TI  - Subnormal serum vitamin B12 and behavioural and psychological symptoms in 
      Alzheimer's disease.
PG  - 415-8
AB  - The objective of this study was to examine whether patients with Alzheimer's 
      disease (AD) with subnormal vitamin B12 levels show more frequent behavioural and 
      psychological symptoms of dementia (BPSD) than AD patients with normal vitamin 
      B12 levels. The design was a prospective case-control study. The study took place 
      at a memory-clinic of a department of geriatric medicine in a teaching hospital. 
      There were seventy-three consecutive outpatients with probable AD, including 61 
      patients with normal and 12 patients with subnormal (<200 pg/ml) vitamin B12. 
      BPSD were measured using the subscales disturbed behaviour and mood of the 
      Nurses' Observation Scale for Geriatric Patients (NOSGER), the Cornell Scale for 
      Depression and the four criteria for personality change in dementia from the 
      International Classification of Diseases (ICD-10). Controlling for dementia 
      duration and degree of severity of the cognitive deficits, there were significant 
      inverse associations between vitamin B12 status and ICD-10 irritability (p=0.045) 
      and NOSGER subscale disturbed behaviour (p=0.015). Low vitamin B12 serum levels 
      are associated with BPSD in AD. Vitamin B12 could play a role in the pathogenesis 
      of behavioural changes in AD.
CI  - Copyright 2000 John Wiley & Sons, Ltd.
FAU - Meins, W
AU  - Meins W
AD  - Memory-Clinic, Department of Geriatric Medicine, Albertinen Hospital, Hamburg, 
      Germany.
FAU - Muller-Thomsen, T
AU  - Muller-Thomsen T
FAU - Meier-Baumgartner, H P
AU  - Meier-Baumgartner HP
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Geriatr Psychiatry
JT  - International journal of geriatric psychiatry
JID - 8710629
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*blood/*psychology
MH  - Case-Control Studies
MH  - Cognition Disorders/diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Vitamin B 12 Deficiency/*blood
EDAT- 2000/05/24 09:00
MHDA- 2000/08/06 11:00
CRDT- 2000/05/24 09:00
PHST- 2000/05/24 09:00 [pubmed]
PHST- 2000/08/06 11:00 [medline]
PHST- 2000/05/24 09:00 [entrez]
AID - 10.1002/(SICI)1099-1166(200005)15:5<415::AID-GPS123>3.0.CO;2-E [pii]
AID - 10.1002/(sici)1099-1166(200005)15:5<415::aid-gps123>3.0.co;2-e [doi]
PST - ppublish
SO  - Int J Geriatr Psychiatry. 2000 May;15(5):415-8. doi: 
      10.1002/(sici)1099-1166(200005)15:5<415::aid-gps123>3.0.co;2-e.