PMID- 10822761
OWN - NLM
STAT- MEDLINE
DCOM- 20000613
LR  - 20061115
IS  - 0036-4355 (Print)
IS  - 0036-4355 (Linking)
VI  - 44
IP  - 6
DP  - 1999 Dec
TI  - [MLL rearrangements in acute leukemias].
PG  - 464-8
AB  - PURPOSE: In present study we have studied MLL rearrangements in a serie of acute 
      myeloid, lymphoblastic and biphenotypic leukaemias. PATIENTS AND METHODS: We 
      analyzed a total of 11 cases: 9 acute myeloid leukaemias (M4 and M5 subtypes in 
      FAB classification), 1 lymphoid leukaemia, and 1 acute biphenotypic leukaemia. We 
      studied bone marrow samples from all patients by using conventional cytogenetic 
      techniques and fluorescence in situ hybridization (FISH) with an MLL probe. We 
      also analyzed the correlation between clinical features and genetic results. 
      RESULTS: Cells from 6 patients showed to contain MLL rearrangements and these 
      arose in all types of leukaemias included in this study. Some MLL rearrangements 
      were detected by FISH in kariotypically normal cases or without cytogenetic 
      evidence of 11q23 aberration. MLL gene duplication has been observed in two cases 
      with M4 and biphenotypic leukaemia, respectively. The presence of MLL gene 
      rearrangements does not shape a group of patients with a common clinical pattern. 
      CONCLUSIONS: MLL rearrangements occurs in a wide variety of leukemias. These 
      rearrangements should be screened by FISH techniques, taking into account that 
      gene duplications could arise in cases with normal karyotype. MLL rearrangements 
      appear to have a considerable clinicopathologic heterogeneity.
FAU - Urioste, M
AU  - Urioste M
AD  - Servicio de Genetica, Fundacion Jimenez Diaz, Madrid.
FAU - Arranz, E
AU  - Arranz E
FAU - Martinez-Delgado, B
AU  - Martinez-Delgado B
FAU - Soto, C
AU  - Soto C
FAU - Roman, A
AU  - Roman A
FAU - Perez, I
AU  - Perez I
FAU - Mayayo, M
AU  - Mayayo M
FAU - Perez-Pons, C
AU  - Perez-Pons C
FAU - Barroso, A
AU  - Barroso A
FAU - Benitez, J
AU  - Benitez J
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Reordenamientos del gen MLL en las leucemias agudas.
PL  - Spain
TA  - Sangre (Barc)
JT  - Sangre
JID - 0404373
SB  - IM
MH  - Adult
MH  - Chromosomes, Human, Pair 11
MH  - *Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myelomonocytic, Acute/*genetics
MH  - *Oncogenes
MH  - Translocation, Genetic
EDAT- 2000/05/24 09:00
MHDA- 2000/06/17 09:00
CRDT- 2000/05/24 09:00
PHST- 2000/05/24 09:00 [pubmed]
PHST- 2000/06/17 09:00 [medline]
PHST- 2000/05/24 09:00 [entrez]
PST - ppublish
SO  - Sangre (Barc). 1999 Dec;44(6):464-8.