PMID- 10825207
OWN - NLM
STAT- MEDLINE
DCOM- 20000707
LR  - 20210526
IS  - 0270-7306 (Print)
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Linking)
VI  - 20
IP  - 12
DP  - 2000 Jun
TI  - Hepatocyte-specific mutation establishes retinoid X receptor alpha as a 
      heterodimeric integrator of multiple physiological processes in the liver.
PG  - 4436-44
AB  - A large number of physiological processes in the adult liver are regulated by 
      nuclear receptors that require heterodimerization with retinoid X receptors 
      (RXRs). In this study, we have used cre-mediated recombination to disrupt the 
      mouse RXRalpha gene specifically in hepatocytes. Although such mice are viable, 
      molecular and biochemical parameters indicate that every one of the examined 
      metabolic pathways in the liver (mediated by RXR heterodimerization with 
      PPARalpha, CARbeta, PXR, LXR, and FXR) is compromised in the absence of RXRalpha. 
      These data demonstrate the presence of a complex circuitry in which RXRalpha is 
      integrated into a number of diverse physiological pathways as a common regulatory 
      component of cholesterol, fatty acid, bile acid, steroid, and xenobiotic 
      metabolism and homeostasis.
FAU - Wan, Y J
AU  - Wan YJ
AD  - Department of Pathology, Harbor-UCLA Medical Center, Torrance, Keck School of 
      Medicine, University of Southern California, Los Angeles, California, USA.
FAU - An, D
AU  - An D
FAU - Cai, Y
AU  - Cai Y
FAU - Repa, J J
AU  - Repa JJ
FAU - Hung-Po Chen, T
AU  - Hung-Po Chen T
FAU - Flores, M
AU  - Flores M
FAU - Postic, C
AU  - Postic C
FAU - Magnuson, M A
AU  - Magnuson MA
FAU - Chen, J
AU  - Chen J
FAU - Chien, K R
AU  - Chien KR
FAU - French, S
AU  - French S
FAU - Mangelsdorf, D J
AU  - Mangelsdorf DJ
FAU - Sucov, H M
AU  - Sucov HM
LA  - eng
GR  - P30 DK048522/DK/NIDDK NIH HHS/United States
GR  - R01 CA053596/CA/NCI NIH HHS/United States
GR  - CA53596/CA/NCI NIH HHS/United States
GR  - DK48522/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - *Homeostasis/genetics
MH  - Liver/*physiology
MH  - Mice
MH  - Mutation
MH  - Receptors, Retinoic Acid/*physiology
MH  - Retinoid X Receptors
MH  - Signal Transduction/physiology
MH  - Transcription Factors/*physiology
PMC - PMC85811
EDAT- 2000/05/29 09:00
MHDA- 2000/07/15 11:00
PMCR- 2000/06/01
CRDT- 2000/05/29 09:00
PHST- 2000/05/29 09:00 [pubmed]
PHST- 2000/07/15 11:00 [medline]
PHST- 2000/05/29 09:00 [entrez]
PHST- 2000/06/01 00:00 [pmc-release]
AID - 0065 [pii]
AID - 10.1128/MCB.20.12.4436-4444.2000 [doi]
PST - ppublish
SO  - Mol Cell Biol. 2000 Jun;20(12):4436-44. doi: 10.1128/MCB.20.12.4436-4444.2000.