PMID- 10825371
OWN - NLM
STAT- MEDLINE
DCOM- 20000725
LR  - 20190513
IS  - 1360-9947 (Print)
IS  - 1360-9947 (Linking)
VI  - 6
IP  - 6
DP  - 2000 Jun
TI  - HLA-G expression in extravillous trophoblasts is an intrinsic property of cell 
      differentiation: a lesson learned from ectopic pregnancies.
PG  - 535-40
AB  - Human leukocyte antigen (HLA)-G is a major histocompatibility gene expressed 
      almost exclusively in extravillous trophoblasts at the fetal-maternal interface. 
      HLA-G may play a role in protecting the fetus from attack by the maternal natural 
      killer cells. The extravillous trophoblasts invade the decidua and maternal 
      spiral arteries. The factors which regulate the cell-specific expression of HLA-G 
      are unknown. In this study we asked if HLA-G is expressed in extravillous 
      trophoblasts that develop outside of their normal cellular environment, as in the 
      case of ectopic pregnancies. Since all ectopic pregnancies implant in the absence 
      of underlying decidua we also used a placenta accreta as an experimental control. 
      We found that HLA-G mRNA and protein were expressed in the extravillous 
      trophoblasts in the 13 ectopic specimens studied. In a case of placenta accreta 
      (which develops without decidua basalis and is therefore adherent to the 
      underlying myometrium), HLA-G mRNA and protein were also expressed. These results 
      suggest that HLA-G expression is induced in a cell autonomous manner rather than 
      determined by appropriate environmental cues.
FAU - Goldman-Wohl, D S
AU  - Goldman-Wohl DS
AD  - Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, 
      Israel.
FAU - Ariel, I
AU  - Ariel I
FAU - Greenfield, C
AU  - Greenfield C
FAU - Hanoch, J
AU  - Hanoch J
FAU - Yagel, S
AU  - Yagel S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Hum Reprod
JT  - Molecular human reproduction
JID - 9513710
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Cell Differentiation
MH  - Chorionic Villi
MH  - Female
MH  - HLA Antigens/genetics/*metabolism
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/genetics/*metabolism
MH  - Humans
MH  - Placenta/cytology/metabolism
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - Pregnancy, Ectopic/*immunology/metabolism/pathology
MH  - RNA, Messenger
MH  - Reference Values
MH  - Trophoblasts/*immunology
EDAT- 2000/05/29 00:00
MHDA- 2000/05/29 00:01
CRDT- 2000/05/29 00:00
PHST- 2000/05/29 00:00 [pubmed]
PHST- 2000/05/29 00:01 [medline]
PHST- 2000/05/29 00:00 [entrez]
AID - 10.1093/molehr/6.6.535 [doi]
PST - ppublish
SO  - Mol Hum Reprod. 2000 Jun;6(6):535-40. doi: 10.1093/molehr/6.6.535.