PMID- 10827160
OWN - NLM
STAT- MEDLINE
DCOM- 20000621
LR  - 20111117
IS  - 0270-9139 (Print)
IS  - 0270-9139 (Linking)
VI  - 31
IP  - 6
DP  - 2000 Jun
TI  - Viral clearance in hepatitis C (1b) infection: relationship with human leukocyte 
      antigen class II in a homogeneous population.
PG  - 1334-7
AB  - The aim of this study was to investigate the possibility of a significant 
      relationship between human leukocyte antigen (HLA) class II and the clearance of 
      hepatitis C virus (HCV). The study group consisted of 156 Irish women who 
      iatrogenically received HCV 1b-contaminated Anti-D immunoglobulin between May 
      1977 and November 1978. Thus, the study population was homogeneous in terms of 
      gender, source of infection, and ethnicity. On Screening in 1994, all individuals 
      were anti-HCV antibody positive by recombinant immunoblot assay, while 46% (n = 
      72) of the group were HCV-positive by reverse transcriptase-polymerase chain 
      reaction (RT-PCR). HLA DRB1 and DQB1 status was molecularly defined by high 
      resolution reverse line probe hybridization methodology. Clearance of HCV 1b was 
      found to be associated with DRB1*01. However, this association was lost after 
      Bonferroni correction for multiple comparisons. Extended haplotype analysis 
      between specific DRB1 and DQB1 allelic combinations identified a significant 
      reduction in the frequency of DQB1*0501 in the presence of DRB1*0701 in the 
      persistently infected individuals in the study group (P <.05). No associations 
      with either viral clearance or persistence were found at the DQB1 locus. Our 
      results suggest that HLA DRB1*01 appears to contribute to the spontaneous 
      resolution of a primary HCV infection in the Irish population. The presence of 
      DRB1*0701 in the absence of DQB1*0501 possibly reflects an influence of this 
      allele in persistence of HCV infection. Defined and homogeneous patient 
      populations offer the best opportunity to illuminate previously disguised 
      immunogenetic factors important in the clearance of HCV 1b.
FAU - Fanning, L J
AU  - Fanning LJ
AD  - Hepatitis C Unit, Department of Medicine, National University of Ireland, Cork, 
      University College Cork, Ireland. L.FANNING@UCC.IE
FAU - Levis, J
AU  - Levis J
FAU - Kenny-Walsh, E
AU  - Kenny-Walsh E
FAU - Wynne, F
AU  - Wynne F
FAU - Whelton, M
AU  - Whelton M
FAU - Shanahan, F
AU  - Shanahan F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Alleles
MH  - Female
MH  - Follow-Up Studies
MH  - Genotype
MH  - HLA-DQ Antigens/analysis
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/analysis
MH  - HLA-DRB1 Chains
MH  - Hepacivirus/*classification/genetics/*isolation & purification
MH  - Hepatitis C/*immunology/*virology
MH  - Histocompatibility Antigens Class II/*analysis/genetics
MH  - Homozygote
MH  - Humans
MH  - Iatrogenic Disease
MH  - RNA, Viral/analysis
EDAT- 2000/05/29 09:00
MHDA- 2000/06/24 11:00
CRDT- 2000/05/29 09:00
PHST- 2000/05/29 09:00 [pubmed]
PHST- 2000/06/24 11:00 [medline]
PHST- 2000/05/29 09:00 [entrez]
AID - S0270913900717526 [pii]
AID - 10.1053/jhep.2000.7437 [doi]
PST - ppublish
SO  - Hepatology. 2000 Jun;31(6):1334-7. doi: 10.1053/jhep.2000.7437.