PMID- 10827400
OWN - NLM
STAT- MEDLINE
DCOM- 20000628
LR  - 20071114
IS  - 0190-9622 (Print)
IS  - 0190-9622 (Linking)
VI  - 42
IP  - 6
DP  - 2000 Jun
TI  - Patients with cutaneous lupus erythematosus who smoke are less responsive to 
      antimalarial treatment.
PG  - 983-7
AB  - BACKGROUND: Reports suggest that cigarette smoking might interfere with the 
      effectiveness of antimalarial therapy as first-line treatment for cutaneous lupus 
      erythematosus. Patients refractory to this treatment often must be treated with 
      potentially more toxic regimens. OBJECTIVE: Our purpose was to examine the 
      effects of cigarette smoking on the therapeutic response to antimalarial agents 
      in patients with discoid lupus erythematosus (DLE) and subacute cutaneous lupus 
      erythematosus (SCLE). METHODS: A total of 61 patients (47 DLE, 14 SCLE) were 
      selected on the basis of the following criteria: (1) skin biopsy was consistent 
      with cutaneous LE, (2) a smoking history was available, and (3) an adequate trial 
      of antimalarial therapy was completed. Patients were classified as antimalarial 
      responders or nonresponders on the basis of descriptions in their medical 
      records. Two-by-two table analysis was performed comparing response rates in 
      smokers versus nonsmokers. RESULTS: A significant difference (P<.0002) in the 
      antimalarial response rate was observed for smokers (40%) versus nonsmokers 
      (90%). CONCLUSION: These results indicate that patients with cutaneous LE who 
      smoke are significantly less likely to respond to antimalarial therapy.
FAU - Jewell, M L
AU  - Jewell ML
AD  - Department of Dermatology, University of North Carolina School of Medicine, 
      Chapel Hill, USA.
FAU - McCauliffe, D P
AU  - McCauliffe DP
LA  - eng
GR  - AR41445/AR/NIAMS NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (Antimalarials)
SB  - IM
MH  - Adult
MH  - Antimalarials/*therapeutic use
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*drug therapy/pathology
MH  - Lupus Erythematosus, Discoid/*drug therapy/pathology
MH  - Male
MH  - Smoking/*adverse effects
MH  - Treatment Outcome
EDAT- 2000/05/29 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/05/29 09:00
PHST- 2000/05/29 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/05/29 09:00 [entrez]
AID - S0190-9622(00)90290-1 [pii]
PST - ppublish
SO  - J Am Acad Dermatol. 2000 Jun;42(6):983-7.