PMID- 10831130
OWN - NLM
STAT- MEDLINE
DCOM- 20000828
LR  - 20190921
IS  - 0143-4004 (Print)
IS  - 0143-4004 (Linking)
VI  - 21 Suppl A
DP  - 2000 Mar-Apr
TI  - HLA-G polymorphisms and molecule function--questions and more questions--a 
      review.
PG  - S86-92
AB  - Human leukocyte antigen (HLA)-G is a non-classical HLA-class I antigen which is 
      predominantly expressed on invasive trophoblastic cells and is postulated to be a 
      mediator of maternal-fetal tolerance. HLA-G interacts with NK cells, can present 
      nonamer peptides and binds CD8 in an analogous manner to classical HLA-I. The 
      HLA-G protein exists in soluble and membrane-bound isoforms generated through 
      alternative splicing. Although initially considered to be non-polymorphic, 
      variations of the HLA-G DNA sequence have been reported which led to the 
      definition of a limited number of HLA-G alleles including the Null-allele 
      G*0105N. Whereas the HLA-G DNA sequence shows a high degree of conservation in 
      positions which are essential for classical HLA-I molecule functions, polymorphic 
      sites in HLA-G are not congruent with sites of high nucleotide variability in 
      classical HLA. The identification of two females with recurrent spontaneous 
      abortions who are homozygous for the G*0105N Null-allele re-opens the discussion 
      about the role of HLA-G in pregnancy and underlines the need of a systematic 
      analysis of the different hypotheses of HLA-G function in vivo.
FAU - van der Ven, K
AU  - van der Ven K
AD  - University of Bonn, Department of Obstetrics and Gynecology, Germany.
FAU - Pfeiffer, K
AU  - Pfeiffer K
FAU - Skrablin, S
AU  - Skrablin S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Alleles
MH  - Alternative Splicing
MH  - Female
MH  - Genes, MHC Class I
MH  - HLA Antigens/chemistry/*genetics/physiology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/chemistry/*genetics/physiology
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - *Polymorphism, Genetic
MH  - Pregnancy
MH  - Pregnancy Complications/immunology
MH  - Pregnancy Maintenance/genetics/immunology
MH  - Receptors, Antigen, T-Cell/metabolism
RF  - 21
EDAT- 2000/06/01 09:00
MHDA- 2000/09/02 11:01
CRDT- 2000/06/01 09:00
PHST- 2000/06/01 09:00 [pubmed]
PHST- 2000/09/02 11:01 [medline]
PHST- 2000/06/01 09:00 [entrez]
AID - S0143400499905155 [pii]
AID - 10.1053/plac.1999.0515 [doi]
PST - ppublish
SO  - Placenta. 2000 Mar-Apr;21 Suppl A:S86-92. doi: 10.1053/plac.1999.0515.