PMID- 10833112
OWN - NLM
STAT- MEDLINE
DCOM- 20000906
LR  - 20190826
IS  - 0004-8291 (Print)
IS  - 0004-8291 (Linking)
VI  - 30
IP  - 2
DP  - 2000 Apr
TI  - Vitamin D deficiency and secondary hyperparathyroidism: clinical and biochemical 
      associations in older non-institutionalised Southern Tasmanians.
PG  - 209-14
AB  - AIM: To determine the prevalence and associations of vitamin D (25-OHD) 
      deficiency in a sample of older Tasmanian subjects. METHODS: A cross-sectional 
      survey of: 109 patients with a mean age of 79 years (range 60-101 years) 
      consecutively admitted to a short stay geriatric rehabilitation ward; 52 
      community dwelling subjects with a mean age of 75 years (range 64-88 years). 
      Subjects answered a questionnaire, had anthropometric measurements and underwent 
      venepuncture. RESULTS: The main outcome measure was 25 hydroxy vitamin D (25-OHD) 
      level with deficiency defined as <28 nmol/L. Vitamin D deficiency was found in 
      67% and secondary hyperparathyroidism in 49% of the hospitalised group. Vitamin D 
      deficiency was also found in 17% of the community group, in particular one in 
      three residents of Independent Living Units was deficient. Subjects who were 
      deficient were older (80 years vs 76 years [p<0.001]), had lower body mass index 
      (23.7 kg/m2 vs 25.9 kg/m2 [p<0.001]) and had a lower serum albumin (35 gm/L vs 39 
      gm/L [p<0.001]). Deficient subjects had poorer physical functional status 
      (p=0.02) and lower activity levels (p<0.001) and reported less habitual sun 
      exposure (p<0.001). Biochemical measures such as parathyroid hormone, alkaline 
      phosphatase and calcium were weakly predictive of vitamin D levels. By stepwise 
      multiple regression analysis, the only significant predictors of vitamin D levels 
      were the Frenchay Activity Index, albumin and calcium. CONCLUSION: Vitamin D 
      deficiency and secondary hyperparathyroidism is common in community living older 
      people who are hospitalised in Southern Tasmania and is associated with 
      increasing age, poor physical function and activity and low reported sun 
      exposure.
FAU - Inderjeeth, C A
AU  - Inderjeeth CA
AD  - Department of Geriatric Medicine, Royal Hobart Hospital, Tasmania. 
      Charles.Inderjeeth@health.wa.gov.au
FAU - Nicklason, F
AU  - Nicklason F
FAU - Al-Lahham, Y
AU  - Al-Lahham Y
FAU - Greenaway, T M
AU  - Greenaway TM
FAU - Jones, G
AU  - Jones G
FAU - Parameswaran, V V
AU  - Parameswaran VV
FAU - David, R
AU  - David R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Australia
TA  - Aust N Z J Med
JT  - Australian and New Zealand journal of medicine
JID - 1264322
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Cross-Sectional Studies
MH  - Female
MH  - Frail Elderly
MH  - Health Policy
MH  - Humans
MH  - Hyperparathyroidism/epidemiology/*etiology/prevention & control
MH  - Inpatients/statistics & numerical data
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Statistics, Nonparametric
MH  - Tasmania/epidemiology
MH  - Vitamin D/analogs & derivatives/blood
MH  - Vitamin D Deficiency/*complications/epidemiology/prevention & control
EDAT- 2000/06/01 09:00
MHDA- 2000/09/09 11:01
CRDT- 2000/06/01 09:00
PHST- 2000/06/01 09:00 [pubmed]
PHST- 2000/09/09 11:01 [medline]
PHST- 2000/06/01 09:00 [entrez]
AID - 10.1111/j.1445-5994.2000.tb00809.x [doi]
PST - ppublish
SO  - Aust N Z J Med. 2000 Apr;30(2):209-14. doi: 10.1111/j.1445-5994.2000.tb00809.x.