PMID- 10833424
OWN - NLM
STAT- MEDLINE
DCOM- 20000710
LR  - 20221207
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 272
IP  - 2
DP  - 2000 Jun 7
TI  - A neuronal NO synthase (NOS1) gene polymorphism is associated with asthma.
PG  - 391-4
AB  - Recent family-based studies have revealed evidence for linkage of chromosomal 
      region 12q to both asthma and high total serum immunoglobulin E (IgE) levels. 
      Among the candidate genes in this region for asthma is neuronal nitric oxide 
      synthase (NOS1). We sought a genetic association between a polymorphism in the 
      NOS1 gene and the diagnosis of asthma, using a case-control design. Frequencies 
      for allele 17 and 18 of a CA repeat in exon 29 of the NOS1 gene were 
      significantly different between 490 asthmatic and 350 control subjects. Allele 17 
      was more common in the asthmatics (0.83 vs 0.76, or 1.49 [95% CI 1.17-1.90], P = 
      0.013) while allele 18 was less common in the asthmatics (0.06 vs 0.12, or 0.49 
      [95% CI 0.34-0. 69], P = 0.0004). To confirm these results we genotyped an 
      additional 1131 control subjects and found the frequencies of alleles 17 and 18 
      to be virtually identical to those ascertained in our original control subjects. 
      Total serum IgE was not associated with any allele of the polymorphism. These 
      findings provide support, from case-control association analysis, for NOS1 as a 
      candidate gene for asthma.
CI  - Copyright 2000 Academic Press.
FAU - Grasemann, H
AU  - Grasemann H
AD  - Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 
      Boston, MA 02115, USA.
FAU - Yandava, C N
AU  - Yandava CN
FAU - Storm van's Gravesande, K
AU  - Storm van's Gravesande K
FAU - Deykin, A
AU  - Deykin A
FAU - Pillari, A
AU  - Pillari A
FAU - Ma, J
AU  - Ma J
FAU - Sonna, L A
AU  - Sonna LA
FAU - Lilly, C
AU  - Lilly C
FAU - Stampfer, M J
AU  - Stampfer MJ
FAU - Israel, E
AU  - Israel E
FAU - Silverman, E K
AU  - Silverman EK
FAU - Drazen, J M
AU  - Drazen JM
LA  - eng
GR  - HL-56383/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 1.14.13.39 (NOS1 protein, human)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asthma/*enzymology/*genetics/immunology
MH  - Case-Control Studies
MH  - Dinucleotide Repeats/genetics
MH  - Exons/genetics
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Models, Genetic
MH  - Nitric Oxide Synthase/*genetics
MH  - Nitric Oxide Synthase Type I
MH  - Odds Ratio
MH  - Polymorphism, Genetic/*genetics
MH  - United States
MH  - White People/genetics
EDAT- 2000/06/02 09:00
MHDA- 2000/07/15 11:00
CRDT- 2000/06/02 09:00
PHST- 2000/06/02 09:00 [pubmed]
PHST- 2000/07/15 11:00 [medline]
PHST- 2000/06/02 09:00 [entrez]
AID - S0006-291X(00)92794-3 [pii]
AID - 10.1006/bbrc.2000.2794 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2000 Jun 7;272(2):391-4. doi: 10.1006/bbrc.2000.2794.