PMID- 10833993
OWN - NLM
STAT- MEDLINE
DCOM- 20000628
LR  - 20180217
IS  - 0001-5547 (Print)
IS  - 0001-5547 (Linking)
VI  - 44
IP  - 3
DP  - 2000 May-Jun
TI  - Detection of trisomy 12 by fluorescence in situ hybridization on archival 
      cytopathologic material in chronic lymphocytic leukemia/small lymphocytic 
      lymphoma.
PG  - 368-74
AB  - OBJECTIVE: To evaluate fluorescence in situ hybridization (FISH) for the 
      detection of trisomy 12 in archival cytologic specimens of chronic lymphocytic 
      leukemia/small lymphocytic lymphoma. STUDY DESIGN: The cytopathology database was 
      searched for all cases of chronic lymphocytic leukemia/small lymphocytic 
      lymphoma. Six cases of chronic lymphocytic leukemia/small lymphocytic lymphoma 
      obtained by fine needle aspiration and one case of small lymphocytic lymphoma 
      with plasmacytoid features were analyzed for trisomy 12 by FISH. These cases had 
      been archived between 1 week to 16 months prior to analysis. RESULTS: We detected 
      trisomy 12 in four of the six cases of small lymphocytic lymphoma/chronic 
      lymphocytic leukemia. The case of small lymphocytic lymphoma with plasmacytoid 
      features was negative for trisomy 12. CONCLUSION: Detection of trisomy 12 by FISH 
      can be effectively performed on routinely prepared, stained and coverslipped 
      archival cytologic material.
FAU - Liu, K
AU  - Liu K
AD  - Department of Pathology, Duke University Medical Center, Durham, North Carolina 
      27710, USA.
FAU - Dodd, L G
AU  - Dodd LG
FAU - Powers, J A
AU  - Powers JA
FAU - Bigner, S H
AU  - Bigner SH
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Acta Cytol
JT  - Acta cytologica
JID - 0370307
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosomes, Human, Pair 12
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis/*genetics/pathology
MH  - Leukemia, Lymphoid/diagnosis/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - *Trisomy
EDAT- 2000/06/02 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/06/02 09:00
PHST- 2000/06/02 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/06/02 09:00 [entrez]
AID - 10.1159/000328480 [doi]
PST - ppublish
SO  - Acta Cytol. 2000 May-Jun;44(3):368-74. doi: 10.1159/000328480.