PMID- 10836352
OWN - NLM
STAT- MEDLINE
DCOM- 20000809
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 13
IP  - 1
DP  - 1999 Jan
TI  - Activation of lymphocytes and increased interleukin-5 levels in bronchoalveolar 
      lavage fluid in acute eosinophilic pneumonia.
PG  - 217-20
AB  - Acute eosinophilic pneumonia (AEP) is a recently described illness and the number 
      of case reports has increased during the last few years. However, the role of 
      interleukin (IL)-5 and activated lymphocytes in the pathogenesis or activity of 
      AEP is still not clear. The clinical features, lymphocyte surface analysis and 
      IL-5 concentrations in bronchoalveolar lavage fluid (BALF) and peripheral blood 
      (PB) of a young female patient with AEP are described before and at 2 weeks, 4 
      weeks and 6 months after a 3-day course of i.v. methylprednisolone. Serum and 
      BALF concentrations of IL-5 before treatment were 5,200 and 8,400 pg x mL(-1), 
      respectively. Activated CD4 lymphocytes bearing CD25 and human leukocyte antigen 
      (HLA)-DR in BALF were higher than in PB. Treatment caused a rapid fall in these 
      cells and levels of IL-5 in BALF returned to normal levels in parallel with 
      clinical improvement. There was no evidence of recurrence after cessation of 
      steroid therapy. In contrast, eosinophilia in BALF persisted for 4 weeks after 
      steroid therapy in spite of normalization of the chest radiograph and arterial 
      blood gases. The number of CD8+CD11b- (suppressor/cytotoxic) T-cells subsequently 
      increased while the number of CD8+CD11b+ cells decreased. These results suggest 
      that activated CD4 cells and interleukin-5 elevation contribute to the 
      development of acute eosinophilic pneumonia rather than persistent eosinophilia 
      in the lung and that a short course of steroid therapy may effectively control 
      acute eosinophilic pneumonia.
FAU - Taniguchi, H
AU  - Taniguchi H
AD  - The Second Dept of Internal Medicine, Nagasaki University School of Medicine, 
      Japan.
FAU - Kadota, J
AU  - Kadota J
FAU - Fujii, T
AU  - Fujii T
FAU - Matsubara, Y
AU  - Matsubara Y
FAU - Katoh, S
AU  - Katoh S
FAU - Mukae, H
AU  - Mukae H
FAU - Matsukura, S
AU  - Matsukura S
FAU - Kohno, S
AU  - Kohno S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Interleukin-5)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Bronchoalveolar Lavage Fluid/*chemistry
MH  - Female
MH  - Humans
MH  - Interleukin-5/*analysis
MH  - *Lymphocyte Activation
MH  - Pulmonary Eosinophilia/*diagnosis/*immunology
EDAT- 2000/06/03 09:00
MHDA- 2000/08/12 11:00
CRDT- 2000/06/03 09:00
PHST- 2000/06/03 09:00 [pubmed]
PHST- 2000/08/12 11:00 [medline]
PHST- 2000/06/03 09:00 [entrez]
AID - 10.1034/j.1399-3003.1999.13a40.x [doi]
PST - ppublish
SO  - Eur Respir J. 1999 Jan;13(1):217-20. doi: 10.1034/j.1399-3003.1999.13a40.x.