PMID- 10836492
OWN - NLM
STAT- MEDLINE
DCOM- 20000925
LR  - 20190910
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 24
IP  - 3
DP  - 2000 Apr
TI  - Open field is more sensitive than automated activity monitor in documenting 
      ouabain-induced hyperlocomotion in the development of an animal model for bipolar 
      illness.
PG  - 455-62
AB  - 1. Intracerebroventricular (i.c.v.) administration of ouabain to rats induces 
      motor hyper- and hypoactivity that have been hypothesized to model the mania and 
      depression of bipolar illness, respectively. 2. The extent of ouabain-induced 
      change in activity may vary according to the test environment. 3. To determine 
      the degree of differential response to i.c.v. ouabain in the open field and 
      automated activity monitors, the authors examined a large number of animals 
      (n=40) in both environments. 4. I.c.v. ouabain produced a four-fold increase in 
      open field activity versus i.c.v. artificial cerebrospinal fluid (aCSF) (mean +/- 
      SD: 258.7 +/- 316.61 vs. 84.8 +/- 86.16 squares traversed) (t = 2.648, P = 
      0.011), but did not alter horizontal activity in automated activity monitors 
      (8193.5 +/- 4902.52 vs. 7088.47 +/- 3046.85 beam interruptions) (t = 0.847, P = 
      0.4). This increase in activity persisted for at least one week (161.0 +/- 186.35 
      for i.c.v. ouabain vs. 46.1 +/- 47.46 for i.c.v. aCSF, P = 0.065). 5. Open field 
      is superior to automated activity monitors in capturing ouabain-induced 
      hyperlocomotion response.
FAU - Decker, S
AU  - Decker S
AD  - Department of Psychiatry and Behavioral Sciences, University of Louisville School 
      of Medicine, Kentucky 40292, USA.
FAU - Grider, G
AU  - Grider G
FAU - Cobb, M
AU  - Cobb M
FAU - Li, X P
AU  - Li XP
FAU - Huff, M O
AU  - Huff MO
FAU - El-Mallakh, R S
AU  - El-Mallakh RS
FAU - Levy, R S
AU  - Levy RS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Enzyme Inhibitors)
RN  - 5ACL011P69 (Ouabain)
SB  - IM
MH  - Animals
MH  - Bipolar Disorder/*physiopathology
MH  - Disease Models, Animal
MH  - Enzyme Inhibitors/administration & dosage/*pharmacology
MH  - Exploratory Behavior/*drug effects
MH  - Male
MH  - Movement Disorders
MH  - Ouabain/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2000/06/03 09:00
MHDA- 2000/09/30 11:01
CRDT- 2000/06/03 09:00
PHST- 2000/06/03 09:00 [pubmed]
PHST- 2000/09/30 11:01 [medline]
PHST- 2000/06/03 09:00 [entrez]
AID - S0278584699001116 [pii]
AID - 10.1016/s0278-5846(99)00111-6 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2000 Apr;24(3):455-62. doi: 
      10.1016/s0278-5846(99)00111-6.