PMID- 10836493
OWN - NLM
STAT- MEDLINE
DCOM- 20000925
LR  - 20190910
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 24
IP  - 3
DP  - 2000 Apr
TI  - Effects of 3,4-methylenedioxy-methamphetamine (MDMA) on anxiety in mice tested in 
      the light-dark box.
PG  - 463-72
AB  - 1. The effects of acute administration of 3,4-methylenedioxymethamphetamine 
      (MDMA; "ecstasy") on anxiety tested in the light/dark box were examined in albino 
      male mice of the OF.1 strain. 2. Animals were evaluated in the light/dark test 30 
      min after injection of MDMA (1, 8, and 15 mg/kg, i.p) or saline. The following 
      parameters were recorded (for 5 min); (a) number of exploratory rearings in the 
      light and dark sections; (b) number of transitions between the lit and dark 
      areas; (c) time spent in the light and dark areas; (d) latency of the initial 
      movement from the light to the dark area, and (e) locomotor activity in light 
      area. 3. MDMA (8 and 15 mg/kg) produced a significant reduction in exploratory 
      activity (rearings and transitions), without decreasing motility, in comparison 
      with saline-treated mice. However, time spent in lit/dark compartments was not 
      significantly affected by the drug, which could be a consequence of the 
      anti-exploratory properties of MDMA. 4. Overall, the behavioral profile found in 
      the light/dark test indicates an anxiogenic-like activity of MDMA in mice. It is 
      suggested, however, that animal models of anxiety which emphasize a social 
      interaction could be more sensitive to the effects of this substance.
FAU - Maldonado, E
AU  - Maldonado E
AD  - Area de Psicobiologia, Facultad de Psicologia, Universidad de Malaga, Spain.
FAU - Navarro, J F
AU  - Navarro JF
LA  - eng
PT  - Journal Article
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Anxiety/*drug therapy/physiopathology
MH  - Disease Models, Animal
MH  - Exploratory Behavior
MH  - Hallucinogens/administration & dosage/*pharmacology
MH  - Light
MH  - Male
MH  - Mice
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
EDAT- 2000/06/03 09:00
MHDA- 2000/09/30 11:01
CRDT- 2000/06/03 09:00
PHST- 2000/06/03 09:00 [pubmed]
PHST- 2000/09/30 11:01 [medline]
PHST- 2000/06/03 09:00 [entrez]
AID - S0278584699001128 [pii]
AID - 10.1016/s0278-5846(99)00112-8 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2000 Apr;24(3):463-72. doi: 
      10.1016/s0278-5846(99)00112-8.