PMID- 10837182
OWN - NLM
STAT- MEDLINE
DCOM- 20000727
LR  - 20131121
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 181
IP  - 6
DP  - 2000 Jun
TI  - Liposomal amphotericin B and amphotericin B-deoxycholate show different 
      immunoregulatory effects on human peripheral blood mononuclear cells.
PG  - 2003-10
AB  - Conventional preparations of amphotericin B (AmB) at established therapeutic 
      doses are known to increase nonspecific immune responses. It remains to be 
      established whether higher doses of the less toxic liposomal preparation of AmB 
      maintains a beneficial effect on the immune response to fungal infections. 
      Examination of the effect of treatment of human peripheral blood mononuclear 
      cells from healthy subjects with various doses of both liposomal AmB (L-AmB) and 
      deoxycholate AmB (d-AmB) on proliferation, cell viability, and percentage of 
      apoptosis demonstrated that, although both L-AmB and d-AmB at low doses 
      significantly increased nonspecific proliferative responses, L-AmB, but not 
      d-AmB, treatment maintained this beneficial effect at higher doses. High doses of 
      d-AmB, but not L-AmB, resulted in significantly decreased cell viability and 
      increased apoptosis. This study provides further evidence in healthy human 
      subjects for choosing L-AmB over conventional preparations in the clinical 
      treatment of fungal infections requiring systemic high-dose treatment with AmB.
FAU - Reyes, E
AU  - Reyes E
AD  - Laboratory of Immune System Diseases and Oncology, Department of Medicine, 
      Universidad de Alcala, Carretera Madrid-Barcelona, 28871 Alcala de Henares 
      (Madrid), Spain.
FAU - Cardona, J
AU  - Cardona J
FAU - Prieto, A
AU  - Prieto A
FAU - Bernstein, E D
AU  - Bernstein ED
FAU - Rodriguez-Zapata, M
AU  - Rodriguez-Zapata M
FAU - Pontes, M J
AU  - Pontes MJ
FAU - Alvarez-Mon, M
AU  - Alvarez-Mon M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20000605
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Antifungal Agents)
RN  - 0 (Liposomes)
RN  - 005990WHZZ (Deoxycholic Acid)
RN  - 7XU7A7DROE (Amphotericin B)
SB  - IM
MH  - Adjuvants, Immunologic/*pharmacology
MH  - Amphotericin B/administration & dosage/*pharmacology
MH  - Antifungal Agents/*pharmacology
MH  - Apoptosis/drug effects
MH  - Cell Survival/drug effects
MH  - Deoxycholic Acid/administration & dosage/*pharmacology
MH  - Humans
MH  - Leukocytes, Mononuclear/*drug effects/immunology
MH  - Liposomes
MH  - Lymphocyte Activation/drug effects
MH  - Macrophages/drug effects/immunology
EDAT- 2000/06/06 09:00
MHDA- 2000/08/01 11:00
CRDT- 2000/06/06 09:00
PHST- 1999/11/29 00:00 [received]
PHST- 2000/03/06 00:00 [revised]
PHST- 2000/06/06 09:00 [pubmed]
PHST- 2000/08/01 11:00 [medline]
PHST- 2000/06/06 09:00 [entrez]
AID - JID991459 [pii]
AID - 10.1086/315517 [doi]
PST - ppublish
SO  - J Infect Dis. 2000 Jun;181(6):2003-10. doi: 10.1086/315517. Epub 2000 Jun 5.