PMID- 10837897
OWN - NLM
STAT- MEDLINE
DCOM- 20000817
LR  - 20190831
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 121
IP  - 1
DP  - 2000 May 11
TI  - Ethanol-induced alterations in the expression of neurotrophic factors in the 
      developing rat central nervous system.
PG  - 97-107
AB  - Neonatal rats were exposed to ethanol throughout gestation, or during the early 
      postnatal period (postnatal days 4-10 (P4-10)), and enzyme-linked immunoabsorbent 
      assays were subsequently conducted in order to assess nerve growth factor (NGF), 
      brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) protein 
      content in hippocampus, septum, cortex/striatum and cerebellum. These 
      determinations revealed that following prenatal ethanol treatment, there were 
      significant ethanol-induced increases in NGF in P1 cortex/striatum, but no 
      changes in any of the three neurotrophic factors (NTFs) in the other brain 
      regions. Cortex/striatal NGF protein returned to control levels by P10. Following 
      early postnatal exposure, BDNF was elevated in hippocampus and cortex/striatum 
      (assessed on P10), and NGF was also enhanced in cortex/striatum at this age. 
      Hippocampal and cortex/striatal BDNF returned to control levels by P21, but 
      cortex/striatal NGF levels remained enhanced at this age. This NTF did not differ 
      in ethanol and control animals by P60, however. The possible significance of 
      elevated levels of NTFs as a function of ethanol exposure is discussed, and it is 
      speculated that while such alterations could play a protective role, increases in 
      these substances during critical developmental periods could also prove to be 
      deleterious, and could even contribute to certain of the neuropathologies which 
      have been observed following developmental ethanol exposure.
FAU - Heaton, M B
AU  - Heaton MB
AD  - University of Florida Brain Institute, Department of Neuroscience, Center for 
      Alcohol Research, University of Florida College of Medicine, Box 100244, 
      Gainesville, FL 32610-0244, USA. heaton@ufbi.ufl.ed
FAU - Mitchell, J J
AU  - Mitchell JJ
FAU - Paiva, M
AU  - Paiva M
FAU - Walker, D W
AU  - Walker DW
LA  - eng
GR  - AA00200/AA/NIAAA NIH HHS/United States
GR  - AA10480/AA/NIAAA NIH HHS/United States
GR  - T32 AA07561/AA/NIAAA NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 3K9958V90M (Ethanol)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain/*embryology/*metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Central Nervous System Depressants/blood/*pharmacology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Ethanol/blood/*pharmacology
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/metabolism
MH  - Nerve Growth Factor/metabolism
MH  - Nerve Growth Factors/*metabolism
MH  - Neurotrophin 3/metabolism
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Long-Evans
EDAT- 2000/06/06 09:00
MHDA- 2000/08/19 11:00
CRDT- 2000/06/06 09:00
PHST- 2000/06/06 09:00 [pubmed]
PHST- 2000/08/19 11:00 [medline]
PHST- 2000/06/06 09:00 [entrez]
AID - S0165380600000328 [pii]
AID - 10.1016/s0165-3806(00)00032-8 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 2000 May 11;121(1):97-107. doi: 
      10.1016/s0165-3806(00)00032-8.