PMID- 10841346
OWN - NLM
STAT- MEDLINE
DCOM- 20000906
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 11
IP  - 7
DP  - 2000 May 15
TI  - Detection and localization of BDNF in vestibular nuclei during the postnatal 
      development of the rat.
PG  - 1401-5
AB  - The changes in expression and the subcellular localization of brain-derived 
      neurotrophic factor (BDNF) protein in the rat vestibular nuclear complex (VNC), 
      have been investigated at different postnatal stages. Immunoblotting and ELISA 
      analyses showed a down-regulation of BDNF protein expression in VNC with age. In 
      addition, observations by confocal microscopy revealed that BDNF is mainly 
      located in neuronal somata at postnatal day 8 (P8) and restricted to processes by 
      P15. These results support the idea that BDNF could have different roles in the 
      VNC according to the stage of development The protein could act as a neurotrophic 
      factor in embryonic and early postnatal stages whereas in later developmental 
      stages of the VNC it could be involved in neuronal maturation and regulation of 
      neuronal circuitry.
FAU - Montcouquiol, M E
AU  - Montcouquiol ME
AD  - INSERM U432, Neurobiologie et developpement du systeme vestibulaire, Universite 
      de Montpellier II, France.
FAU - Sans, N A
AU  - Sans NA
FAU - Travo, C
AU  - Travo C
FAU - Sans, A
AU  - Sans A
FAU - Valat, J
AU  - Valat J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Antibody Specificity
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*analysis/biosynthesis/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Microscopy, Confocal
MH  - Rats
MH  - Synapses/chemistry
MH  - Vestibular Nuclei/*chemistry/*growth & development/metabolism
EDAT- 2000/06/07 09:00
MHDA- 2000/09/09 11:01
CRDT- 2000/06/07 09:00
PHST- 2000/06/07 09:00 [pubmed]
PHST- 2000/09/09 11:01 [medline]
PHST- 2000/06/07 09:00 [entrez]
AID - 10.1097/00001756-200005150-00010 [doi]
PST - ppublish
SO  - Neuroreport. 2000 May 15;11(7):1401-5. doi: 10.1097/00001756-200005150-00010.