PMID- 10841894
OWN - NLM
STAT- MEDLINE
DCOM- 20000804
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 868
IP  - 1
DP  - 2000 Jun 16
TI  - Trophic interactions between brain-derived neurotrophic factor and s100beta on 
      cultured serotonergic neurons.
PG  - 113-8
AB  - Brain-derived neurotrophic factor (BDNF) and S100beta stimulate serotonergic 
      neurons in fetal rat raphe primary cultures grown under serum-free conditions. 
      BDNF (50 ng/ml) treatment for 3 h enhanced S100beta immunoreactivity in both 
      raphe and hippocampal glial cells. Combined treatment with BDNF and S100beta for 
      3 days increased the soma area of 5-HT neurons, but not the neurite length. Our 
      results suggest that BDNF and S100beta, which regulate different signal 
      transduction cascades, interact to exert complimentary effects on neuronal 
      maturation by acting sequentially, not concurrently.
FAU - Nishi, M
AU  - Nishi M
AD  - Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, 
      Kawaramachi Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan. 
      nmayumi@koto.kpu-m.ac.jp
FAU - Kawata, M
AU  - Kawata M
FAU - Azmitia, E C
AU  - Azmitia EC
LA  - eng
GR  - MH55250/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Culture Media, Serum-Free)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (S100 Proteins)
RN  - 10028-17-8 (Tritium)
RN  - 333DO1RDJY (Serotonin)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Calcium-Binding Proteins/*pharmacology
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - Culture Media, Serum-Free/pharmacology
MH  - Drug Interactions
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Nerve Growth Factors/*pharmacology
MH  - Neurons/*cytology/*drug effects/enzymology
MH  - Raphe Nuclei/cytology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - S100 Calcium Binding Protein beta Subunit
MH  - *S100 Proteins
MH  - Serotonin/*pharmacokinetics
MH  - Tritium
EDAT- 2000/06/08 09:00
MHDA- 2000/08/12 11:00
CRDT- 2000/06/08 09:00
PHST- 2000/06/08 09:00 [pubmed]
PHST- 2000/08/12 11:00 [medline]
PHST- 2000/06/08 09:00 [entrez]
AID - S0006-8993(00)02201-0 [pii]
AID - 10.1016/s0006-8993(00)02201-0 [doi]
PST - ppublish
SO  - Brain Res. 2000 Jun 16;868(1):113-8. doi: 10.1016/s0006-8993(00)02201-0.