PMID- 10842362
OWN - NLM
STAT- MEDLINE
DCOM- 20000809
LR  - 20161124
IS  - 1058-8388 (Print)
IS  - 1058-8388 (Linking)
VI  - 218
IP  - 2
DP  - 2000 Jun
TI  - Formation of a full complement of cranial proprioceptors requires multiple 
      neurotrophins.
PG  - 359-70
AB  - Inactivation of neurotrophin-3 (NT3) completely blocks the development of limb 
      proprioceptive neurons and their end organs, the muscle spindles. We examined 
      whether cranial proprioceptive neurons of the trigeminal mesencephalic nucleus 
      (TMN) require NT3, brain-derived neurotrophic factor (BDNF) or neurotrophin-4 
      (NT4) for their development. Complements of TMN neurons and masticatory muscle 
      spindles were decreased by 62% in NT3 null mutants, 33% in BDNF null mutants, and 
      10% in NT4 null mutant mice at birth. The extent of proprioceptive deficiencies 
      differed among different masticatory muscles, particularly in NT3 null mice. 
      Masticatory muscles of embryonic mice heterozygous for the NT3(lacZneo) or 
      BDNF(lacZ) reporter genes expressed both NT3 and BDNF, consistent with 
      target-derived neurotrophin support of TMN neurons. Although more than 90% of TMN 
      neurons expressed TrkB as well as TrkC receptor proteins by immunocytochemistry 
      in wild-type newborns, TrkC or TrkB null mice exhibited only partial 
      proprioceptive deficiencies similar to those present in NT3 or BDNF;NT4 null 
      mice. Thus, in terms of the survival outcome, two main subpopulations of TMN 
      neurons may exist during embryogenesis, one dependent on TrkC/NT3 functioning and 
      the other utilizing TrkB/BDNF signaling. The differential dependence of TMN 
      neurons on neurotrophins may reflect differential accessibility of the neurons to 
      limiting amounts of NT3, BDNF, or NT4 in target tissues, especially if the tissue 
      distribution or levels of BDNF, NT3, and NT4 were dynamically regulated both 
      spatially and temporally.
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Fan, G
AU  - Fan G
AD  - Whitehead Institute for Biomedical Research, Massachusetts Institute of 
      Technology, Cambridge, USA.
FAU - Copray, S
AU  - Copray S
FAU - Huang, E J
AU  - Huang EJ
FAU - Jones, K
AU  - Jones K
FAU - Yan, Q
AU  - Yan Q
FAU - Walro, J
AU  - Walro J
FAU - Jaenisch, R
AU  - Jaenisch R
FAU - Kucera, J
AU  - Kucera J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Dyn
JT  - Developmental dynamics : an official publication of the American Association of 
      Anatomists
JID - 9201927
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
EIN - Dev Dyn 2002 Dec;225(4):602
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Gene Dosage
MH  - Gene Expression
MH  - Masticatory Muscles/embryology/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Knockout
MH  - Muscle Spindles/embryology/metabolism
MH  - Nerve Growth Factors/genetics/*metabolism
MH  - Neurons
MH  - Neurotrophin 3/genetics/*metabolism
MH  - Receptor, trkB/genetics/metabolism
MH  - Receptor, trkC/genetics/metabolism
MH  - Sensory Receptor Cells/*embryology
MH  - Skull
MH  - Trigeminal Nuclei/*embryology/metabolism
EDAT- 2000/06/08 09:00
MHDA- 2000/08/12 11:00
CRDT- 2000/06/08 09:00
PHST- 2000/06/08 09:00 [pubmed]
PHST- 2000/08/12 11:00 [medline]
PHST- 2000/06/08 09:00 [entrez]
AID - 10.1002/(SICI)1097-0177(200006)218:2<359::AID-DVDY9>3.0.CO;2-L [pii]
AID - 10.1002/(SICI)1097-0177(200006)218:2<359::AID-DVDY9>3.0.CO;2-L [doi]
PST - ppublish
SO  - Dev Dyn. 2000 Jun;218(2):359-70. doi: 
      10.1002/(SICI)1097-0177(200006)218:2<359::AID-DVDY9>3.0.CO;2-L.