PMID- 10842590
OWN - NLM
STAT- MEDLINE
DCOM- 20000627
LR  - 20131121
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 884
DP  - 1999 Nov 28
TI  - Neurotrophins, NMDA receptors, and nitric oxide in development and protection of 
      the auditory system.
PG  - 131-42
AB  - Neurotrophic factors are secreted peptides that when interacting with specific 
      classes of membrane receptors activate intracellular signaling cascades that 
      prevents neuronal death during embryonic development. The establishment of 
      gene-targeted null mutant mice for the neurotrophic factors, brain-derived 
      neurotrophic factor (BDNF) and neurotrophin-3 (NT3) has led to the discovery that 
      they are crucial trophic factors for the survival of auditory and vestibular 
      neurons during development. BDNF is the major survival factor for vestibular 
      ganglion neurons, while NT-3 only support a small number of these neurons. In the 
      cochlea, auditory type I neurons require NT3 for their survival, whereas type II 
      neurons depend on BDNF. With this information at hand recent progress has been 
      made regarding the prevention of aminoglycoside-induced hearing loss in the adult 
      guinea pig. These results and the mechanisms leading to hair cell damage are 
      discussed in this paper.
FAU - Agerman, K
AU  - Agerman K
AD  - Department of Medical Biochemistry, Karolinska Institute, Stockholm, Sweden.
FAU - Canlon, B
AU  - Canlon B
FAU - Duan, M
AU  - Duan M
FAU - Ernfors, P
AU  - Ernfors P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Aminoglycosides)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Aminoglycosides
MH  - Animals
MH  - Anti-Bacterial Agents/adverse effects/pharmacokinetics
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology
MH  - Deafness/chemically induced/*drug therapy/prevention & control
MH  - Ear, Inner/physiology
MH  - Excitatory Amino Acid Antagonists/pharmacology/*therapeutic use
MH  - Guinea Pigs
MH  - Hair Cells, Auditory/drug effects/growth & development/*metabolism
MH  - Mice
MH  - Neurotrophin 3/*metabolism/pharmacology/*therapeutic use
MH  - Nitric Oxide/*physiology
MH  - RNA, Messenger/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/drug effects
RF  - 44
EDAT- 2000/06/08 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/06/08 09:00
PHST- 2000/06/08 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/06/08 09:00 [entrez]
PST - ppublish
SO  - Ann N Y Acad Sci. 1999 Nov 28;884:131-42.