PMID- 10842601
OWN - NLM
STAT- MEDLINE
DCOM- 20000627
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 884
DP  - 1999 Nov 28
TI  - Neurotrophic factors in the auditory periphery.
PG  - 292-304
AB  - Many of the neurotrophic factors promote the survival of developing peripheral 
      sensory neurons, and they might be useful as therapeutic agents in the adult 
      neuronal systems. During development, neurotrophin-3 (NT-3) and brain-derived 
      neurotrophic factor (BDNF) mRNAs are expressed in the auditory sensory 
      epithelium, which composes the peripheral target field of the cochlear (spiral) 
      neurons. NT-3 mRNA is also expressed in the inner hair cells of the mature organ 
      of Corti. mRNAs encoding their signal-transducing receptors, TrkC and TrkB, 
      respectively, are expressed in the cochlear neurons. In addition to 
      neurotrophins, which seem to have an important role during development, another 
      neurotrophic factor, glial cell-line-derived neurotrophic factor (GDNF), seems to 
      be involved in the maintenance of postnatal auditory neurons. In the present 
      work, the cellular distribution of neurotrophins and GDNF in the developing and 
      adult rat inner ear are compared. The effects of recombinant neurotrophins and 
      GDNF on dissociated cochlear neurons in vitro are also compared. Recently, NT-3 
      and BDNF were used in vivo as therapeutic agents to protect guinea pig cochlear 
      neurons from aminoglycoside-induced degeneration and GDNF from noise-induced 
      degeneration. These data demonstrate that NT-3, BDNF, and GDNF might be potential 
      candidates for prevention of degeneration of the auditory nerve in man.
FAU - Qun, L X
AU  - Qun LX
AD  - Department of Otorhinolaryngology, University of Helsinki, Finland.
FAU - Pirvola, U
AU  - Pirvola U
FAU - Saarma, M
AU  - Saarma M
FAU - Ylikoski, J
AU  - Ylikoski J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Gdnf protein, rat)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology
MH  - Cells, Cultured
MH  - Cochlea/drug effects/embryology/*metabolism
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - *Nerve Growth Factors
MH  - Nerve Tissue Proteins/*metabolism/pharmacology
MH  - Neuroprotective Agents/metabolism/pharmacology
MH  - Neurotrophin 3/*metabolism/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2000/06/08 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/06/08 09:00
PHST- 2000/06/08 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/06/08 09:00 [entrez]
AID - 10.1111/j.1749-6632.1999.tb08649.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 1999 Nov 28;884:292-304. doi: 
      10.1111/j.1749-6632.1999.tb08649.x.