PMID- 10842602
OWN - NLM
STAT- MEDLINE
DCOM- 20000627
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 884
DP  - 1999 Nov 28
TI  - Rescue and regrowth of sensory nerves following deafferentation by neurotrophic 
      factors.
PG  - 305-11
AB  - Trauma and loss of cochlear inner hair cells causes a series of events that 
      result first in the retraction of the peripheral processes of the auditory nerve, 
      scar formation in the organ of Corti, and over the course of weeks to months 
      (depending on the species) the loss of auditory nerve cell bodies (spiral 
      ganglion cells). Neurotrophic factors play an important role in the mature 
      nervous system as survival factors for maintenance and protection and also can 
      play a role in regrowth. Studies in the cochlea now show that application of 
      exogenous neurotrophic factors can enhance survival of spiral ganglion cells 
      after deafness and induce regrowth of peripheral processes, perhaps by replacing 
      lost endogenous factors. Combinations of factors may be most effective for 
      achieving greatest survival and regrowth. Our studies find that brain-derived 
      neurotrophic factor (BDNF) and glial-line-derived neurotrophic factor (GDNF) are 
      very effective at enhancing spiral ganglion cell survival following deafness from 
      ototoxic drugs or noise. It has also been found that BDNF plus fibroblast growth 
      factor (FGF) is very effective at inducing process regrowth. Electrical 
      stimulation also acts to enhance spiral ganglion cell survival, and the 
      combination of electrical stimulation and neurotrophic factors could prove a most 
      effective intervention.
FAU - Altschuler, R A
AU  - Altschuler RA
AD  - Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506, 
      USA. shuler@umich.edu
FAU - Cho, Y
AU  - Cho Y
FAU - Ylikoski, J
AU  - Ylikoski J
FAU - Pirvola, U
AU  - Pirvola U
FAU - Magal, E
AU  - Magal E
FAU - Miller, J M
AU  - Miller JM
LA  - eng
GR  - DC00274/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Aminoglycosides)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Aminoglycosides
MH  - Animals
MH  - Anti-Bacterial Agents/adverse effects
MH  - Brain-Derived Neurotrophic Factor/*pharmacology/therapeutic use
MH  - Deafness/chemically induced/drug therapy
MH  - Fibroblast Growth Factors/pharmacology/therapeutic use
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Nerve Growth Factors/*pharmacology/therapeutic use
MH  - Nerve Tissue Proteins/*pharmacology/therapeutic use
MH  - Neurons, Afferent/drug effects/physiology
MH  - Spiral Ganglion/*drug effects/physiology
RF  - 33
EDAT- 2000/06/08 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/06/08 09:00
PHST- 2000/06/08 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/06/08 09:00 [entrez]
AID - 10.1111/j.1749-6632.1999.tb08650.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 1999 Nov 28;884:305-11. doi: 
      10.1111/j.1749-6632.1999.tb08650.x.