PMID- 10844597
OWN - NLM
STAT- MEDLINE
DCOM- 20000824
LR  - 20061115
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 57
IP  - 6
DP  - 2000 Jun
TI  - Estrogen effects on triglyceride metabolism in analbuminemic rats.
PG  - 2268-74
AB  - BACKGROUND: Triglyceride (TG) levels are normally lower in female rats, while the 
      opposite is the case in the Nagase analbuminemic rats (NAR). Increased TG levels 
      in normal males are caused by a testosterone-mediated decrease in postheparin 
      (PH) lipoprotein lipase (LpL). Castration of males reduces TG, while castration 
      of females is without effect. TG levels are reduced by castration of the female 
      NAR, suggesting that estrogen rather than testosterone causes 
      hypertriglyceridemia in this strain. The mechanism for this increase is unknown. 
      METHODS: We measured secretion of very-low density lipoprotein (VLDL) TG using 
      Triton WR 1339 clearance as the disappearance from blood of 3H-trioleate and 
      14C-cholesterol-labeled chylomicrons (CM), and the activity of the PH lipases: 
      LpL and hepatic lipase (HL). All were determined in Sprague-Dawley (SD) and NAR 
      female, male, and ovariectomized (OVX) rats. RESULTS: TG levels were 
      significantly greater in female NAR in comparison to all other groups. 
      Ovariectomy of NAR significantly ameliorated hypertriglyceridemia. VLDL TG 
      secretion was significantly greater in intact female NAR compared with all other 
      groups. There were no other differences in VLDL TG secretion among the other 
      groups. The clearance of CM was greatest in female SD rats, and OVX had no 
      effect. NAR cleared CM less well than did SD rats (P < 0.001), but among NAR, 
      clearance was greatest in OVX NAR and male NAR (P < 0. 002). Both PH LpL activity 
      and HL activity were lowest in female NAR (P < 0.05). Ovariectomy partially 
      corrected the defect in HL (P < 0. 05). CONCLUSION: TG levels in female NAR are 
      in part a result of increased VLDL-TG secretion, an effect mediated by estrogen. 
      The presence of an estrogen-mediated catabolic defect that was alleviated by OVX 
      was also observed. This catabolic defect is likely a result of an 
      estrogen-mediated decrease both in LpL and HL expressed only in the presence of 
      analbuminemia.
FAU - Shearer, G C
AU  - Shearer GC
AD  - Division of Nephrology, Department of Medicine UC Davis, Davis, California 95616, 
      USA.
FAU - Joles, J A
AU  - Joles JA
FAU - Jones, H
AU  - Jones H
FAU - Walzem, R L
AU  - Walzem RL
FAU - Kaysen, G A
AU  - Kaysen GA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Chylomicrons)
RN  - 0 (Estrogens)
RN  - 0 (Lipoproteins, VLDL)
RN  - 0 (Serum Albumin)
RN  - 0 (Triglycerides)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.1.1.3 (Lipase)
RN  - EC 3.1.1.34 (Lipoprotein Lipase)
SB  - IM
MH  - Animals
MH  - Blood/metabolism
MH  - Chylomicrons/blood
MH  - Estrogens/*physiology
MH  - Female
MH  - Heparin/pharmacology
MH  - Lipase/blood
MH  - Lipoprotein Lipase/metabolism
MH  - Lipoproteins, VLDL/blood
MH  - Liver/enzymology
MH  - Male
MH  - Ovariectomy
MH  - Rats
MH  - Rats, Mutant Strains
MH  - Rats, Sprague-Dawley
MH  - Serum Albumin/*analysis
MH  - Triglycerides/*blood
EDAT- 2000/06/09 09:00
MHDA- 2000/08/29 11:01
CRDT- 2000/06/09 09:00
PHST- 2000/06/09 09:00 [pubmed]
PHST- 2000/08/29 11:01 [medline]
PHST- 2000/06/09 09:00 [entrez]
AID - S0085-2538(15)46987-X [pii]
AID - 10.1046/j.1523-1755.2000.00087.x [doi]
PST - ppublish
SO  - Kidney Int. 2000 Jun;57(6):2268-74. doi: 10.1046/j.1523-1755.2000.00087.x.