PMID- 10845672
OWN - NLM
STAT- MEDLINE
DCOM- 20001003
LR  - 20190817
IS  - 0168-8278 (Print)
IS  - 0168-8278 (Linking)
VI  - 32
IP  - 5
DP  - 2000 May
TI  - Human leukocyte antigen DRB1 1302 protects against bile duct damage and portal 
      lymphocyte infiltration in patients with chronic hepatitis C.
PG  - 837-42
AB  - BACKGROUND/AIMS: To confirm the immune reaction of hosts in chronic hepatitis C, 
      we examined the association of human leukocyte antigen (HLA) DR with the 
      histopathological outcome including bile duct damage and steatosis, which are 
      characteristic of hepatitis C virus (HCV) infection. METHODS: One hundred and 
      fifty-five patients with chronic HCV infection were examined. The pathological 
      appearance of liver biopsy specimens was evaluated by both Knodell's histological 
      activity index and examination of bile duct damage and steatosis. HLA DRB1 was 
      determined by the polymerase chain reaction sequence-specific oligonucleotide 
      probe method. RESULTS: HLA DRB1 1302 was found with significantly higher 
      frequency in patients without than with bile duct damage (34.8% vs. 4.7%, 
      p=0.0001, p corrected by Bonferroni's inequality method=0.002). It was also found 
      more frequently in patients without marked portal lymphocyte infiltration (28.6% 
      vs. 7.7%, p=0.0015, p corrected by Bonferroni's method=0.03). HLA DRB1 1101 was 
      found more frequently in patients without than with piecemeal necrosis (p=0.004). 
      In contrast, the frequency of HLA DRB1 1502 tended to be higher in patients with 
      than without piecemeal necrosis and marked portal lymphocyte infiltration 
      (p=0.015 and p=0.03, respectively). HLA DRB1 1201 and 0802 were seen more 
      frequently in bile duct damage-negative (p=0.02) and piecemeal necrosis-negative 
      patients (p=0.03), respectively. Interestingly, serum HCV levels of HLA DRB1 
      1302-positive patients were significantly higher than those of 1302-negative 
      patients (mean: 7.7 Meq/ml vs. 3.1 Meq/ml, p=0.0007). CONCLUSION: These findings 
      suggest that some histopathological changes in chronically HCV-infected livers 
      could be caused by the host's immune reaction regulated by HLA DR.
FAU - Haruna, Y
AU  - Haruna Y
AD  - Department of Gastroenterology & Diabetology, Osaka Prefectural General Hospital, 
      Japan.
FAU - Miyamoto, T
AU  - Miyamoto T
FAU - Yasunami, R
AU  - Yasunami R
FAU - Kanda, T
AU  - Kanda T
FAU - Fushimi, H
AU  - Fushimi H
FAU - Kotoh, K
AU  - Kotoh K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Hepatol
JT  - Journal of hepatology
JID - 8503886
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bile Ducts/immunology/*pathology
MH  - Cell Movement/immunology
MH  - Female
MH  - Gene Frequency
MH  - HLA-DR Antigens/genetics/*immunology
MH  - HLA-DRB1 Chains
MH  - Hepacivirus/immunology
MH  - Hepatitis C, Chronic/genetics/*immunology/pathology
MH  - Humans
MH  - Lymphocytes/*immunology/pathology
MH  - Male
MH  - Middle Aged
EDAT- 2000/06/14 09:00
MHDA- 2000/10/07 11:01
CRDT- 2000/06/14 09:00
PHST- 2000/06/14 09:00 [pubmed]
PHST- 2000/10/07 11:01 [medline]
PHST- 2000/06/14 09:00 [entrez]
AID - S0168-8278(00)80254-8 [pii]
AID - 10.1016/s0168-8278(00)80254-8 [doi]
PST - ppublish
SO  - J Hepatol. 2000 May;32(5):837-42. doi: 10.1016/s0168-8278(00)80254-8.