PMID- 10849094
OWN - NLM
STAT- MEDLINE
DCOM- 20000719
LR  - 20190822
IS  - 0309-0167 (Print)
IS  - 0309-0167 (Linking)
VI  - 36
IP  - 6
DP  - 2000 Jun
TI  - Immunoreactivity for cadherins, HGF/SF, met, and erbB-2 in pleural malignant 
      mesotheliomas.
PG  - 522-8
AB  - AIMS: To assess the immunoreactivity of malignant mesotheliomas for N- and 
      E-cadherins, hepatocyte growth factor/scatter factor (HGF/SF) and the tyrosine 
      kinase receptors, met and erbB-2. METHODS AND RESULTS: Pleural malignant 
      mesotheliomas were stained using a standard indirect immunoperoxidase method 
      applied to paraffin sections. Malignant mesotheliomas were immunoreactive for 
      N-cadherin (26/29; 90%), met (29/29; 100%) and erbB-2 (28/29; 97%). Focal 
      immunoreactivity was present for E-cadherin in epithelioid or mixed tumours 
      (14/25; 56%), and for HGF/SF (9/24; 38%). CONCLUSIONS: Expression of N-cadherin 
      supports the diagnosis of malignant mesothelioma and use of appropriate 
      antibodies would be a useful addition to a diagnostic antibody panel. Focal 
      staining for E-cadherin does not exclude mesothelioma. Signalling pathways 
      mediated via met and erbB-2 may play a role in the growth and spread of malignant 
      mesotheliomas.
FAU - Thirkettle, I
AU  - Thirkettle I
AD  - Department of Histopathology/Cytopathology, Norfolk & Norwich Hospital, School of 
      Biological Sciences, University of East Anglia, UK.
FAU - Harvey, P
AU  - Harvey P
FAU - Hasleton, P S
AU  - Hasleton PS
FAU - Ball, R Y
AU  - Ball RY
FAU - Warn, R M
AU  - Warn RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - 0 (Cadherins)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adenocarcinoma/metabolism/pathology
MH  - Cadherins/*analysis
MH  - Hepatocyte Growth Factor/*analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Mesothelioma/*metabolism/pathology
MH  - Neoplasm Metastasis
MH  - Pleural Neoplasms/*metabolism/pathology
MH  - Pleurisy/metabolism/pathology
MH  - Proto-Oncogene Proteins c-met/*analysis
MH  - Receptor, ErbB-2/*analysis
EDAT- 2000/06/10 09:00
MHDA- 2000/07/25 11:00
CRDT- 2000/06/10 09:00
PHST- 2000/06/10 09:00 [pubmed]
PHST- 2000/07/25 11:00 [medline]
PHST- 2000/06/10 09:00 [entrez]
AID - his888 [pii]
AID - 10.1046/j.1365-2559.2000.00888.x [doi]
PST - ppublish
SO  - Histopathology. 2000 Jun;36(6):522-8. doi: 10.1046/j.1365-2559.2000.00888.x.