PMID- 10850387
OWN - NLM
STAT- MEDLINE
DCOM- 20000630
LR  - 20051116
IS  - 1368-4736 (Print)
IS  - 1368-4736 (Linking)
VI  - 5
IP  - 4
DP  - 1999 Dec
TI  - Major salivary gland involvement in graft-versus-host disease: considerations 
      related to pathogenesis, the role of cytokines and therapy.
PG  - 227-32
AB  - Chronic graft-versus-host-disease (GVHD) is an autoimmune-like complication often 
      occurring in patients who have been treated with bone marrow and peripheral blood 
      stem cell transplantation. Various tissues and organs are damaged via the 
      cytotoxicity rendered by the infiltrating donor graft T cells. The mucosal insult 
      is enhanced by the reduced quantity and the altered quality of the saliva, since 
      the salivary glands are a known major target of GVHD. The salivary changes are 
      also expressed by a reduction in related functions, such as anti-infection 
      activity, protection against mechanical and chemical epithelial injuries, 
      assistance in controlling periodontal disease and caries, etc. The purpose of 
      this review is to summarize the data that have been published recently concerning 
      salivary involvement in GVHD and to suggest an underlying mechanism for the 
      disease and its related 'state-of-the-art' therapeutic policy.
FAU - Nagler, R M
AU  - Nagler RM
AD  - Department of Oral and Maxillofacial Surgery, Rambam Medical Center and Faculty 
      of Medicine, Technion-Israel Institute of Technology, Haifa. 
      nagler@tx.technion.ac.il
FAU - Nagler, A
AU  - Nagler A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Cytokines Cell Mol Ther
JT  - Cytokines, cellular & molecular therapy
JID - 9713367
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Cytokines/*metabolism
MH  - *Graft vs Host Disease/drug therapy/immunology/metabolism/pathology
MH  - Humans
MH  - Saliva/chemistry/immunology/metabolism
MH  - Salivary Glands/drug effects/*metabolism
RF  - 49
EDAT- 2000/06/13 09:00
MHDA- 2000/07/08 11:00
CRDT- 2000/06/13 09:00
PHST- 2000/06/13 09:00 [pubmed]
PHST- 2000/07/08 11:00 [medline]
PHST- 2000/06/13 09:00 [entrez]
PST - ppublish
SO  - Cytokines Cell Mol Ther. 1999 Dec;5(4):227-32.