PMID- 10852382
OWN - NLM
STAT- MEDLINE
DCOM- 20000921
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 55
IP  - 4
DP  - 2000 Apr
TI  - HLA DRB1*1501 and intrathecal inflammation in multiple sclerosis.
PG  - 312-8
AB  - CD4 T cells are considered to be pivotal in the pathogenesis of multiple 
      sclerosis (MS), and the human leukocyte antigen (HLA) haplotype associated with 
      DRB1*1501 confers susceptibility to MS in patients of Northern European descent. 
      Some previous studies have suggested an association of DRB1*1501 with T- and 
      B-cell reactivity to specific myelin protein peptides, other studies suggested an 
      association with enhanced cytokine production or intrathecal immunoglobulin (Ig) 
      synthesis. In order to further assess the role of DRB1*1501 in the pathogenesis 
      of MS, we studied intrathecal inflammation and T-cell phenotypes in patients with 
      possible onset symptoms or clinically definite MS. Presence of DRB1*1501 was 
      associated with higher levels of cerebrospinal fluid (CSF) inflammation as 
      assessed by IgG synthesis levels and higher levels of matrix metalloproteinase-9 
      activity. DRB1*1501-positive patients also had a lower percentage of T cells in 
      CSF expressing HLA-DR without co-expressing CD25. These findings suggest that 
      enhanced intrathecal inflammation and an altered T-cell activation status may be 
      of importance in conferring the DRB1*1501-associated susceptibility to MS.
FAU - Sellebjerg, F
AU  - Sellebjerg F
AD  - Department of Neurology, University of Copenhagen, Glostrup Hospital, Denmark. 
      sellebjerg@dadlnet.dk
FAU - Jensen, J
AU  - Jensen J
FAU - Madsen, H O
AU  - Madsen HO
FAU - Svejgaard, A
AU  - Svejgaard A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
MH  - Adult
MH  - Cerebrospinal Fluid/cytology/immunology
MH  - Female
MH  - Flow Cytometry
MH  - HLA-DR Antigens/*immunology
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis/*cerebrospinal fluid/*immunology
MH  - Myelin Sheath/immunology
MH  - Myelitis/*immunology
MH  - Receptors, Interleukin-2/analysis
MH  - T-Lymphocyte Subsets/chemistry/immunology
EDAT- 2000/06/14 09:00
MHDA- 2000/09/23 11:01
CRDT- 2000/06/14 09:00
PHST- 2000/06/14 09:00 [pubmed]
PHST- 2000/09/23 11:01 [medline]
PHST- 2000/06/14 09:00 [entrez]
AID - 10.1034/j.1399-0039.2000.550404.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2000 Apr;55(4):312-8. doi: 10.1034/j.1399-0039.2000.550404.x.